18-Deoxyaldosterone

Chemical compound
  • 188963
UNII
  • S4YT68R2XR
CompTox Dashboard (EPA)
  • DTXSID30947934 Edit this at Wikidata
Chemical and physical dataFormulaC21H28O4Molar mass344.451 g·mol−13D model (JSmol)
  • Interactive image
  • C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4CC5([C@H]3CC[C@@H]5C(=O)CO)CO4
InChI
  • InChI=1S/C21H28O4/c1-20-7-6-13(23)8-12(20)2-3-14-15-4-5-16(17(24)10-22)21(15)9-18(19(14)20)25-11-21/h8,14-16,18-19,22H,2-7,9-11H2,1H3/t14-,15-,16+,18-,19+,20-,21?/m0/s1
  • Key:ZEBLTAXSHAKMDJ-QBSCYWOBSA-N

18-Deoxyaldosterone is a steroidal antimineralocorticoid with mixed agonist–antagonist but predominantly antagonistic activity at the mineralocorticoid receptor.[2]

References

  1. ^ https://pubchem.ncbi.nlm.nih.gov/compound/21125567
  2. ^ Duax WL, Griffin JF, Strong PD, Funder JW, Ulick S (1982). "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American Chemical Society. 104 (25): 7291–7293. doi:10.1021/ja00389a063. ISSN 0002-7863.


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Mineralocorticoid receptor modulators
MRTooltip Mineralocorticoid receptor
Agonists
Antagonists
See also
Receptor/signaling modulators
Mineralocorticoids and antimineralocorticoids
Glucocorticoid receptor modulators
List of corticosteroids
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