ALG14

Protein-coding gene in the species Homo sapiens
ALG14
Identifiers
AliasesALG14, CMS15, UDP-N-acetylglucosaminyltransferase subunit, ALG14 UDP-N-acetylglucosaminyltransferase subunit, IDDEBF, MEPCA
External IDsOMIM: 612866; MGI: 1914039; HomoloGene: 49751; GeneCards: ALG14; OMA:ALG14 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ALG14
Genomic location for ALG14
Band1p21.3Start94,974,405 bp[1]
End95,072,951 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for ALG14
Genomic location for ALG14
Band3|3 G1Start121,085,422 bp[2]
End121,156,743 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • jejunal mucosa

  • mucosa of colon

  • mucosa of sigmoid colon

  • right adrenal gland

  • oral cavity

  • left adrenal gland

  • caput epididymis

  • Achilles tendon

  • palpebral conjunctiva
Top expressed in
  • sciatic nerve

  • retinal pigment epithelium

  • vestibular membrane of cochlear duct

  • calvaria

  • otic placode

  • lumbar spinal ganglion

  • morula

  • genital tubercle

  • carotid body

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
Cellular component
  • integral component of membrane
  • nuclear membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • nucleus
  • UDP-N-acetylglucosamine transferase complex
Biological process
  • dolichol-linked oligosaccharide biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

199857

66789

Ensembl

ENSG00000172339

ENSMUSG00000039887

UniProt

Q96F25

Q9D081

RefSeq (mRNA)

NM_001305242
NM_144988

NM_024178

RefSeq (protein)

NP_001292171
NP_659425

NP_077140

Location (UCSC)Chr 1: 94.97 – 95.07 MbChr 3: 121.09 – 121.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-N-acetylglucosamine transferase subunit ALG14 homolog is a protein that in humans is encoded by the ALG14 gene.[5][6]

Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (this protein) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172339 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039887 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: asparagine-linked glycosylation 14 homolog (S. cerevisiae)".
  6. ^ Chantret I, Dancourt J, Barbat A, Moore SE (March 2005). "Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae". J. Biol. Chem. 280 (10): 9236–42. doi:10.1074/jbc.M413941200. PMID 15615718.
  7. ^ Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.

External links

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gao XD, Tachikawa H, Sato T, et al. (2005). "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation". J. Biol. Chem. 280 (43): 36254–62. doi:10.1074/jbc.M507569200. PMID 16100110.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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