ATP8B3

Protein-coding gene in the species Homo sapiens
ATP8B3
Identifiers
AliasesATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDsOMIM: 605866; MGI: 1914581; HomoloGene: 19034; GeneCards: ATP8B3; OMA:ATP8B3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ATP8B3
Genomic location for ATP8B3
Band19p13.3Start1,782,075 bp[1]
End1,812,276 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ATP8B3
Genomic location for ATP8B3
Band10|10 C1Start80,355,418 bp[2]
End80,374,958 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • buccal mucosa cell

  • stromal cell of endometrium

  • right adrenal gland

  • right adrenal cortex

  • granulocyte

  • testicle

  • left adrenal gland

  • left adrenal cortex
Top expressed in
  • spermatid

  • spermatocyte

  • seminiferous tubule

  • olfactory epithelium

  • embryo

  • facial motor nucleus

  • epiblast

  • islet of Langerhans

  • tail of embryo

  • anterior horn of spinal cord
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • metal ion binding
  • ATPase-coupled intramembrane lipid transporter activity
  • hydrolase activity
  • ATP binding
  • magnesium ion binding
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • membrane
  • plasma membrane
  • acrosomal membrane
  • endoplasmic reticulum
  • cytoplasmic vesicle
  • acrosomal vesicle
Biological process
  • lipid transport
  • Golgi organization
  • phospholipid transport
  • phospholipid translocation
  • binding of sperm to zona pellucida
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

148229

67331

Ensembl

ENSG00000130270

ENSMUSG00000003341

UniProt

O60423

Q6UQ17

RefSeq (mRNA)

NM_001178002
NM_138813

NM_026094

RefSeq (protein)

NP_001171473
NP_620168

NP_080370

Location (UCSC)Chr 19: 1.78 – 1.81 MbChr 10: 80.36 – 80.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.[5]

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130270 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003341 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3". Retrieved 2011-10-22.

External links

Further reading

  • Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (November 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572. S2CID 762447.
  • Harris MJ, Arias IM (July 2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1633 (2): 127–31. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872.
  • Fries AS, Svendsen O (January 1978). "Studies on Tyzzer's disease in rats". Laboratory Animals. 12 (1): 1–4. doi:10.1258/002367778780953297. PMID 146761. S2CID 8184958.
  • Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M (May 2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 106 (18): 7501–6. Bibcode:2009PNAS..106.7501S. doi:10.1073/pnas.0813386106. PMC 2678639. PMID 19416921.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
F-, V-, and A-type ATPase (3.A.2)
H+ (F-type)
H+ (V-type)
A-ATPase
found in Archea
P-type ATPase (3.A.3)
  • 3.A.3.1.2: H+/K+
  • H+/K+ exchanging: ATP4A
  • ATP4B
  • 3.A.3.1.4: H+/K+ transporting, nongastric: ATP12A
  • Other/ungrouped:
  • Na+/K+ – H+
see also ATPase disorders
  • v
  • t
  • e
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
  • ATP4A
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors
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