CENPM

Protein-coding gene in the species Homo sapiens
CENPM
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4P0T, 4WAU

Identifiers
AliasesCENPM, C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
External IDsOMIM: 610152; MGI: 1913820; HomoloGene: 11438; GeneCards: CENPM; OMA:CENPM - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CENPM
Genomic location for CENPM
Band22q13.2Start41,938,737 bp[1]
End41,947,152 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CENPM
Genomic location for CENPM
Band15|15 E1Start82,117,980 bp[2]
End82,128,949 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • ganglionic eminence

  • bronchial epithelial cell

  • bone marrow

  • appendix

  • bone marrow cells

  • lymph node

  • stromal cell of endometrium

  • amniotic fluid

  • spleen
Top expressed in
  • morula

  • secondary oocyte

  • medial ganglionic eminence

  • yolk sac

  • internal carotid artery

  • blastocyst

  • neural tube

  • external carotid artery

  • thymus

  • maxillary prominence
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79019

66570

Ensembl

ENSG00000100162

ENSMUSG00000068101

UniProt

Q9NSP4

Q9CQA0

RefSeq (mRNA)
NM_001002876
NM_001110215
NM_001304370
NM_001304371
NM_001304372

NM_001304373
NM_024053

NM_001080158
NM_025639
NM_178269

RefSeq (protein)
NP_001002876
NP_001103685
NP_001291299
NP_001291300
NP_001291301

NP_001291302
NP_076958

NP_001073627
NP_079915
NP_840000

Location (UCSC)Chr 22: 41.94 – 41.95 MbChr 15: 82.12 – 82.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.[5][6][7]

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.[8][9] Centromere protein M is involved in centromere assembly and immune response.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100162 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068101 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  6. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  7. ^ "Entrez Gene: CENPM centromere protein M".
  8. ^ Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC 1895781. PMID 16391015.
  9. ^ Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID 15183305.
  10. ^ Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID 19711193. S2CID 20345149.

Further reading

  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.

External links

  • Human CENPM genome location and CENPM gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q9NSP4 (Human Centromere protein M (CENPM)) at the PDBe-KB.
  • v
  • t
  • e
Basic
conceptsTypesProcesses
and evolutionStructures
Histone
Centromere
See also


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