CLEC4A

Protein-coding gene in humans
CLEC4A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5B1W, 5B1X

Identifiers
AliasesCLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDsOMIM: 605306; MGI: 1349412; HomoloGene: 49291; GeneCards: CLEC4A; OMA:CLEC4A - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CLEC4A
Genomic location for CLEC4A
Band12p13.31Start8,123,617 bp[1]
End8,138,607 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CLEC4A
Genomic location for CLEC4A
Band6 F2|6 58.18 cMStart123,083,387 bp[2]
End123,120,958 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • blood

  • appendix

  • testicle

  • spleen

  • bone marrow

  • bone marrow cells

  • upper lobe of left lung

  • right lung
Top expressed in
  • granulocyte

  • stroma of bone marrow

  • tibiofemoral joint

  • spermatid

  • embryo

  • spleen

  • Paneth cell

  • submandibular gland

  • seminiferous tubule

  • blood
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • carbohydrate binding
  • calcium ion binding
  • mannose binding
  • metal ion binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • cell surface receptor signaling pathway
  • cell adhesion
  • stimulatory C-type lectin receptor signaling pathway
  • adaptive immune response
  • immune system process
  • innate immune response
  • negative regulation of cytokine production
  • plasmacytoid dendritic cell antigen processing and presentation
  • negative regulation of tumor necrosis factor production
  • CD8-positive, alpha-beta T cell activation
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50856

26888

Ensembl

ENSG00000111729

ENSMUSG00000030148

UniProt

Q9UMR7

Q9QZ15

RefSeq (mRNA)

NM_016184
NM_194447
NM_194448
NM_194450

NM_001170332
NM_001170333
NM_011999

RefSeq (protein)

NP_057268
NP_919429
NP_919430
NP_919432

NP_001163803
NP_001163804
NP_036129

Location (UCSC)Chr 12: 8.12 – 8.14 MbChr 6: 123.08 – 123.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.[5][6]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111729 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030148 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973–83. doi:10.4049/jimmunol.163.4.1973. PMID 10438934.
  6. ^ a b "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".

Further reading

  • Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
  • Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants". Biochem. Biophys. Res. Commun. 281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID 11178971.
  • Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation". J. Leukoc. Biol. 71 (5): 871–80. doi:10.1189/jlb.71.5.871. PMID 11994513. S2CID 36809172.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.
  • Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents". Biochem. Biophys. Res. Commun. 310 (3): 767–73. doi:10.1016/j.bbrc.2003.09.077. PMID 14550269.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2". Mol. Immunol. 43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID 16360206.
  • Lorentzen JC, Flornes L, Eklöw C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors". Arthritis Rheum. 56 (8): 2620–32. doi:10.1002/art.22813. PMID 17665455.

External links


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