DCP1B

Protein found in humans
DCP1B
Identifiers
AliasesDCP1B, DCP1, hDcp1b, decapping mRNA 1B
External IDsOMIM: 609843; MGI: 2442404; HomoloGene: 51881; GeneCards: DCP1B; OMA:DCP1B - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for DCP1B
Genomic location for DCP1B
Band12p13.33Start1,946,053 bp[1]
End2,004,535 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for DCP1B
Genomic location for DCP1B
Band6|6 F1Start119,175,253 bp[2]
End119,221,616 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle layer of sigmoid colon

  • smooth muscle tissue

  • body of uterus

  • gonad

  • myometrium

  • right adrenal gland

  • right adrenal cortex

  • popliteal artery

  • tibial arteries

  • left adrenal gland
Top expressed in
  • seminiferous tubule

  • superior cervical ganglion

  • spermatocyte

  • spermatid

  • otolith organ

  • utricle

  • Rostral migratory stream

  • genital tubercle

  • spinal ganglia

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • enzyme regulator activity
  • enzyme activator activity
  • protein binding
  • mRNA binding
  • hydrolase activity
Cellular component
  • P-body
  • membrane
  • intracellular membrane-bounded organelle
  • nucleus
  • cytoplasm
  • cytosol
Biological process
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • positive regulation of catalytic activity
  • deadenylation-independent decapping of nuclear-transcribed mRNA
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • exonucleolytic catabolism of deadenylated mRNA
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

196513

319618

Ensembl

ENSG00000151065
ENSG00000284850

ENSMUSG00000041477

UniProt

Q8IZD4

B9EIX0

RefSeq (mRNA)

NM_152640
NM_001319292

NM_001033379

RefSeq (protein)

NP_001306221
NP_689853

NP_001028551

Location (UCSC)Chr 12: 1.95 – 2 MbChr 6: 119.18 – 119.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.[5][6][7]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM][7]

References

  1. ^ a b c ENSG00000284850 GRCh38: Ensembl release 89: ENSG00000151065, ENSG00000284850 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041477 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
  6. ^ Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
  7. ^ a b "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Further reading

  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
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