DNPEP

Protein-coding gene in the species Homo sapiens
DNPEP
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4DYO

Identifiers
AliasesDNPEP, ASPEP, DAP, aspartyl aminopeptidase
External IDsOMIM: 611367 MGI: 1278328 HomoloGene: 6110 GeneCards: DNPEP
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DNPEP
Genomic location for DNPEP
Band2q35Start219,372,043 bp[1]
End219,400,022 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DNPEP
Genomic location for DNPEP
Band1|1 C4Start75,284,540 bp[2]
End75,294,634 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • canal of the cervix

  • gastric mucosa

  • left uterine tube

  • upper lobe of left lung

  • skin of abdomen

  • gastrocnemius muscle

  • right lung

  • body of stomach

  • right coronary artery

  • sperm
Top expressed in
  • intestinal villus

  • internal carotid artery

  • external carotid artery

  • aortic valve

  • ascending aorta

  • endocardial cushion

  • Paneth cell

  • atrium

  • seminiferous tubule

  • superior cervical ganglion
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • peptidase activity
  • zinc ion binding
  • aminopeptidase activity
  • protein binding
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • metalloaminopeptidase activity
  • identical protein binding
Cellular component
  • blood microparticle
  • nucleus
  • cytosol
  • cytoplasm
  • extracellular region
Biological process
  • proteolysis
  • peptide metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23549

13437

Ensembl

ENSG00000123992

ENSMUSG00000026209

UniProt

Q9ULA0

Q9Z2W0

RefSeq (mRNA)
NM_012100
NM_001319116
NM_001319117
NM_001319118
NM_001319119

NM_001319120
NM_001319121
NM_001319122

NM_001110831
NM_016878

RefSeq (protein)
NP_001306045
NP_001306046
NP_001306047
NP_001306048
NP_001306049

NP_001306050
NP_001306051
NP_036232
NP_001306050.1
NP_001306051.1

NP_001104301
NP_058574

Location (UCSC)Chr 2: 219.37 – 219.4 MbChr 1: 75.28 – 75.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.[5][6]

Function

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in the general metabolism of intracellular proteins.[6]

See also

  • icon Biology portal

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123992 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026209 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilk S, Wilk E, Magnusson RP (Jun 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". The Journal of Biological Chemistry. 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644.
  6. ^ a b "Entrez Gene: DNPEP aspartyl aminopeptidase".

Further reading

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Prieto I, Hermoso F, de Gasparo M, Vargas F, Alba F, Segarra AB, Banegas I, Ramírez M (May 2003). "Angiotensinase activities in the kidney of renovascular hypertensive rats". Peptides. 24 (5): 755–60. CiteSeerX 10.1.1.379.1582. doi:10.1016/S0196-9781(03)00121-9. PMID 12895663. S2CID 16379232.
  • Wilk S, Wilk E, Magnusson RP (Nov 2002). "Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase". Archives of Biochemistry and Biophysics. 407 (2): 176–83. doi:10.1016/S0003-9861(02)00494-0. PMID 12413488.

External links

  • The MEROPS online database for peptidases and their inhibitors: M18.002
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Aspartyl aminopeptidase (DNPEP)
  • v
  • t
  • e
3.4.11-19: Exopeptidase
3.4.11
3.4.13
3.4.14
3.4.15
3.4.16
3.4.17
Other/ungrouped
3.4.21-25: Endopeptidase3.4.99: Unknown


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