FAM57B

Protein-coding gene in the species Homo sapiens
TLCD3B
Identifiers
AliasesTLCD3B, FP1188, family with sequence similarity 57 member B, FAM57B, TLC domain ceramide synthase 3B, TLC domain containing 3B, CORD22
External IDsOMIM: 615175; MGI: 1916202; HomoloGene: 69491; GeneCards: TLCD3B; OMA:TLCD3B - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for TLCD3B
Genomic location for TLCD3B
Band16p11.2Start30,024,427 bp[1]
End30,052,978 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for TLCD3B
Genomic location for TLCD3B
Band7|7 F3Start126,396,840 bp[2]
End126,429,391 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • right hemisphere of cerebellum

  • ganglionic eminence

  • vena cava

  • right frontal lobe

  • pons

  • cingulate gyrus

  • anterior cingulate cortex

  • prefrontal cortex
Top expressed in
  • neural layer of retina

  • Rostral migratory stream

  • deep cerebellar nuclei

  • retinal pigment epithelium

  • pontine nuclei

  • cerebellar vermis

  • lobe of cerebellum

  • medial vestibular nucleus

  • inferior colliculus

  • epithelium of lens
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • sphingosine N-acyltransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
Biological process
  • ceramide biosynthetic process
  • negative regulation of fat cell differentiation
  • lipid metabolism
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83723

68952

Ensembl

ENSG00000149926

ENSMUSG00000058966

UniProt

Q71RH2

Q7TNV1

RefSeq (mRNA)

NM_031478
NM_001318504
NM_001352173

NM_001146347
NM_026884
NM_029978

RefSeq (protein)

NP_001305433
NP_113666
NP_001339102

NP_001139819
NP_081160
NP_084254

Location (UCSC)Chr 16: 30.02 – 30.05 MbChr 7: 126.4 – 126.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein FAM57B is a protein that in humans is encoded by the FAM57B gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149926 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058966 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: FAM57B family with sequence similarity 57, member B".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


  • v
  • t
  • e