FBRS

Protein-coding gene in the species Homo sapiens
FBRS
Identifiers
AliasesFBRS, FBS, FBS1, fibrosin
External IDsOMIM: 608601; MGI: 104648; HomoloGene: 79554; GeneCards: FBRS; OMA:FBRS - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for FBRS
Genomic location for FBRS
Band16p11.2Start30,658,431 bp[1]
End30,670,810 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for FBRS
Genomic location for FBRS
Band7|7 F3Start127,078,371 bp[2]
End127,090,883 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • right uterine tube

  • anterior pituitary

  • granulocyte

  • right lobe of thyroid gland

  • skin of leg

  • cerebellar vermis

  • left lobe of thyroid gland

  • gastric mucosa
Top expressed in
  • granulocyte

  • zygote

  • secondary oocyte

  • thymus

  • spleen

  • primary oocyte

  • lip

  • adrenal gland

  • esophagus

  • bone marrow
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • growth factor activity
Cellular component
  • extracellular space
Biological process
  • positive regulation of fibroblast proliferation
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64319

14123

Ensembl

ENSG00000156860

ENSMUSG00000042423

UniProt

Q9HAH7

Q8R089

RefSeq (mRNA)

NM_001105079
NM_022452

NM_010183

RefSeq (protein)

NP_001098549

NP_034313

Location (UCSC)Chr 16: 30.66 – 30.67 MbChr 7: 127.08 – 127.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable fibrosin-1 long transcript protein is a protein that in humans is encoded by the FBRS gene.[5][6][7]

Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998).[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156860 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042423 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Prakash S, Robbins PW, Wyler DJ (Apr 1995). "Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin". Proc Natl Acad Sci U S A. 92 (6): 2154–8. Bibcode:1995PNAS...92.2154P. doi:10.1073/pnas.92.6.2154. PMC 42442. PMID 7892239.
  6. ^ Prakash S, Robbins PW (Nov 1998). "Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine". DNA Cell Biol. 17 (10): 879–84. doi:10.1089/dna.1998.17.879. PMID 9809749.
  7. ^ a b "Entrez Gene: FBS1 fibrosin 1".

Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Prakash S, Nanji AA, Robbins PW (1999). "Fibrosin: A novel lymphokine in alcohol-induced fibrosis". Exp. Mol. Pathol. 67 (1): 40–9. doi:10.1006/exmp.1999.2274. PMID 10493891.
  • Prakash S, Robbins PW (2002). "Fibrosin: a novel lymphokine in wound healing". Exp. Mol. Pathol. 71 (3): 247–55. doi:10.1006/exmp.2001.2402. PMID 11733950.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Prakash S, Paul WE, Robbins PW (2007). "Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts". Exp. Mol. Pathol. 82 (1): 42–8. doi:10.1016/j.yexmp.2006.06.008. PMID 17083929.


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