GFM2

Protein-coding gene in the species Homo sapiens
GFM2
Identifiers
AliasesGFM2, EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDsOMIM: 606544; MGI: 2444783; HomoloGene: 6238; GeneCards: GFM2; OMA:GFM2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GFM2
Genomic location for GFM2
Band5q13.3Start74,721,206 bp[1]
End74,767,147 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GFM2
Genomic location for GFM2
Band13|13 D1Start97,274,445 bp[2]
End97,317,703 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • tibialis anterior muscle

  • bronchial epithelial cell

  • deltoid muscle

  • epithelium of nasopharynx

  • secondary oocyte

  • mucosa of ileum

  • cardiac muscle tissue of right atrium

  • right uterine tube

  • nasal epithelium
Top expressed in
  • muscle of thigh

  • otic vesicle

  • sternocleidomastoid muscle

  • otic placode

  • temporal muscle

  • right kidney

  • saccule

  • triceps brachii muscle

  • digastric muscle

  • skeletal muscle tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • translation elongation factor activity
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
Cellular component
  • mitochondrial matrix
  • mitochondrion
Biological process
  • mitochondrial translational termination
  • mitochondrial translational elongation
  • ribosome disassembly
  • protein biosynthesis
  • mitochondrial translation
  • translational elongation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84340

320806

Ensembl

ENSG00000164347

ENSMUSG00000021666

UniProt

Q969S9

Q8R2Q4

RefSeq (mRNA)

NM_001281302
NM_032380
NM_170681
NM_170691

NM_001146043
NM_001271463
NM_001271464
NM_001271465
NM_177266

RefSeq (protein)

NP_001268231
NP_115756
NP_733781
NP_733792
NP_733792.1

NP_001139515
NP_001258392
NP_001258393
NP_001258394
NP_796240

Location (UCSC)Chr 5: 74.72 – 74.77 MbChr 13: 97.27 – 97.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. [5][6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164347 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021666 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
  6. ^ "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
  7. ^ Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.

External links


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