GLG1

Protein-coding gene in the species Homo sapiens
GLG1
Identifiers
AliasesGLG1, CFR-1, ESL-1, MG-160, MG160, golgi glycoprotein 1
External IDsOMIM: 600753; MGI: 104967; HomoloGene: 7533; GeneCards: GLG1; OMA:GLG1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for GLG1
Genomic location for GLG1
Band16q23.1Start74,447,427 bp[1]
End74,607,144 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for GLG1
Genomic location for GLG1
Band8 E1|8 57.98 cMStart111,881,053 bp[2]
End111,985,848 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • renal medulla

  • nipple

  • tibia

  • pylorus

  • cardia

  • external globus pallidus

  • corpus callosum

  • ventral tegmental area

  • spinal ganglia
Top expressed in
  • efferent ductule

  • calvaria

  • epithelium of lens

  • Rostral migratory stream

  • internal carotid artery

  • ciliary body

  • central gray substance of midbrain

  • lacrimal gland

  • right ventricle

  • stroma of bone marrow
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • fibroblast growth factor binding
  • signaling receptor binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • Golgi apparatus
  • extracellular exosome
  • membrane
  • Golgi membrane
  • extracellular matrix
Biological process
  • bone morphogenesis
  • negative regulation of protein processing
  • regulation of chondrocyte differentiation
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • leukocyte migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2734

20340

Ensembl

ENSG00000090863

ENSMUSG00000003316

UniProt

Q92896

Q61543

RefSeq (mRNA)

NM_001145666
NM_001145667
NM_012201

NM_009149
NM_001368315

RefSeq (protein)

NP_001139138
NP_001139139
NP_036333

NP_033175
NP_001355244

Location (UCSC)Chr 16: 74.45 – 74.61 MbChr 8: 111.88 – 111.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgi apparatus protein 1 is a protein that in humans is encoded by the GLG1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090863 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003316 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mourelatos Z, Gonatas JO, Nycum LM, Gonatas NK, Biegel JA (Feb 1996). "Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization". Genomics. 28 (2): 354–5. doi:10.1006/geno.1995.1156. PMID 8530051.
  6. ^ Steegmaier M, Levinovitz A, Isenmann S, Borges E, Lenter M, Kocher HP, Kleuser B, Vestweber D (Mar 1995). "The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor". Nature. 373 (6515): 615–20. Bibcode:1995Natur.373..615S. doi:10.1038/373615a0. PMID 7531823. S2CID 1602373.
  7. ^ "Entrez Gene: GLG1 golgi apparatus protein 1".

Further reading

  • Burrus LW, Zuber ME, Lueddecke BA, Olwin BB (1992). "Identification of a cysteine-rich receptor for fibroblast growth factors". Mol. Cell. Biol. 12 (12): 5600–9. doi:10.1128/MCB.12.12.5600. PMC 360499. PMID 1448090.
  • Croul S, Mezitis SG, Stieber A, et al. (1990). "Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus". J. Histochem. Cytochem. 38 (7): 957–63. doi:10.1177/38.7.2355176. PMID 2355176.
  • Mourelatos Z, Gonatas JO, Cinato E, Gonatas NK (1997). "Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus". DNA Cell Biol. 15 (12): 1121–8. doi:10.1089/dna.1996.15.1121. PMID 8985126.
  • Steegmaier M, Borges E, Berger J, et al. (1997). "The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface". J. Cell Sci. 110 (6): 687–94. doi:10.1242/jcs.110.6.687. PMID 9099943.
  • Olofsson A, Hellman U, Ten Dijke P, et al. (1997). "Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160". Biochem. J. 324 (Pt 2): 427–34. doi:10.1042/bj3240427. PMC 1218448. PMID 9182700.
  • Wild MK, Huang MC, Schulze-Horsel U, et al. (2001). "Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1". J. Biol. Chem. 276 (34): 31602–12. doi:10.1074/jbc.M104844200. PMID 11404363.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yamaguchi F, Morrison RS, Gonatas NK, et al. (2003). "Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas". Int. J. Oncol. 22 (5): 1045–9. doi:10.3892/ijo.22.5.1045. PMID 12684670.
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Ahn J, Febbraio M, Silverstein RL (2005). "A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization". J. Cell Sci. 118 (Pt 8): 1725–31. doi:10.1242/jcs.02310. PMID 15797922.


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