GPIHBP1

Protein-coding gene in the species Homo sapiens
GPIHBP1
Identifiers
AliasesGPIHBP1, GPI-HBP1, HYPL1D, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
External IDsOMIM: 612757; MGI: 1915703; HomoloGene: 18651; GeneCards: GPIHBP1; OMA:GPIHBP1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for GPIHBP1
Genomic location for GPIHBP1
Band8q24.3Start143,213,218 bp[1]
End143,217,170 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for GPIHBP1
Genomic location for GPIHBP1
Band15|15 D3Start75,468,477 bp[2]
End75,471,330 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • C1 segment

  • abdominal fat

  • subcutaneous adipose tissue

  • substantia nigra

  • left ventricle

  • sural nerve

  • upper lobe of left lung

  • right lung

  • muscle of leg
Top expressed in
  • right lung

  • right lung lobe

  • interventricular septum

  • brown adipose tissue

  • myocardium of ventricle

  • muscle of thigh

  • soleus muscle

  • thoracic diaphragm

  • tibialis anterior muscle

  • digastric muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • lipid binding
  • protein transmembrane transporter activity
  • lipase binding
  • chylomicron binding
  • lipoprotein particle binding
  • protein binding
Cellular component
  • membrane
  • intracellular anatomical structure
  • basolateral plasma membrane
  • apical plasma membrane
  • anchored component of external side of plasma membrane
  • high-density lipoprotein particle
  • anchored component of membrane
  • extracellular region
  • plasma membrane
  • external side of plasma membrane
Biological process
  • protein transmembrane transport
  • response to heparin
  • regulation of lipoprotein lipase activity
  • intracellular protein transport
  • protein import
  • protein localization to cell surface
  • cholesterol homeostasis
  • transcytosis
  • protein stabilization
  • positive regulation of lipoprotein lipase activity
  • triglyceride homeostasis
  • positive regulation of chylomicron remnant clearance
  • retinoid metabolic process
  • chylomicron remodeling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

338328

68453

Ensembl

ENSG00000277494

ENSMUSG00000022579

UniProt

Q8IV16

Q9D1N2

RefSeq (mRNA)

NM_178172
NM_001301772

NM_026730
NM_001347039
NM_001361294

RefSeq (protein)

NP_001288701
NP_835466

NP_001333968
NP_081006
NP_001348223

Location (UCSC)Chr 8: 143.21 – 143.22 MbChr 15: 75.47 – 75.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) also known as high density lipoprotein-binding protein 1 is a protein that in humans is encoded by the GPIHBP1 gene.[5]

Function

Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277494 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022579 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1".
  6. ^ Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG (April 2007). "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons". Cell Metab. 5 (4): 279–91. doi:10.1016/j.cmet.2007.02.002. PMC 1913910. PMID 17403372.

Further reading

  • Coca-Prieto, I.; Kroupa, O.; Gonzalez-Santos, P.; Magne, J.; Olivecrona, G.; Ehrenborg, E.; Valdivielso, P. (2011). "Childhood-onset chylomicronaemia with reduced plasma lipoprotein lipase activity and mass: Identification of a novelGPIHBP1mutation". Journal of Internal Medicine. 270 (3): 224–228. doi:10.1111/j.1365-2796.2011.02361.x. PMID 21314738. S2CID 10833906.
  • Olivecrona, G.; Ehrenborg, E.; Semb, H.; Makoveichuk, E.; Lindberg, A.; Hayden, M. R.; Gin, P.; Davies, B. S. J.; Weinstein, M. M.; Fong, L. G.; Beigneux, A. P.; Young, S. G.; Olivecrona, T.; Hernell, O. (2009). "Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia". The Journal of Lipid Research. 51 (6): 1535–1545. doi:10.1194/jlr.M002717. PMC 3035517. PMID 20026666.
  • Charriere, S.; Peretti, N.; Bernard, S.; Di Filippo, M.; Sassolas, A.; Merlin, M.; Delay, M.; Debard, C.; Lefai, E.; Lachaux, A.; Moulin, P.; Marcais, C. (2011). "GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia". Journal of Clinical Endocrinology & Metabolism. 96 (10): E1675–E1679. doi:10.1210/jc.2011-1444. PMID 21816778.
  • Gin, P.; Yin, L.; Davies, B. S. J.; Weinstein, M. M.; Ryan, R. O.; Bensadoun, A.; Fong, L. G.; Young, S. G.; Beigneux, A. P. (2008). "The Acidic Domain of GPIHBP1 is Important for the Binding of Lipoprotein Lipase and Chylomicrons". Journal of Biological Chemistry. 283 (43): 29554–29562. doi:10.1074/jbc.M802579200. PMC 2662032. PMID 18713736.
  • Young, S. G.; Davies, B. S. J.; Voss, C. V.; Gin, P.; Weinstein, M. M.; Tontonoz, P.; Reue, K.; Bensadoun, A.; Fong, L. G.; Beigneux, A. P. (2011). "GPIHBP1, an endothelial cell transporter for lipoprotein lipase". The Journal of Lipid Research. 52 (11): 1869–1884. doi:10.1194/jlr.R018689. PMC 3196223. PMID 21844202.
  • Beigneux, A. P.; Franssen, R.; Bensadoun, A.; Gin, P.; Melford, K.; Peter, J.; Walzem, R. L.; Weinstein, M. M.; Davies, B. S. J.; Kuivenhoven, J. A.; Kastelein, J. J. P.; Fong, L. G.; Dallinga-Thie, G. M.; Young, S. G. (2009). "Chylomicronemia with a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (6): 956–962. doi:10.1161/ATVBAHA.109.186577. PMC 2811263. PMID 19304573.
  • Sonnenburg, W. K.; Yu, D.; Lee, E. C.; Xiong, W.; Gololobov, G.; Key, B.; Gay, J.; Wilganowski, N.; Hu, Y.; Zhao, S.; Schneider, M.; Ding, Z. -M.; Zambrowicz, B. P.; Landes, G.; Powell, D. R.; Desai, U. (2009). "GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal of Lipid Research. 50 (12): 2421–2429. doi:10.1194/jlr.M900145-JLR200. PMC 2781314. PMID 19542565.
  • Young, S. G.; Davies, B. S.; Fong, L. G.; Gin, P.; Weinstein, M. M.; Bensadoun, A. ?; Beigneux, A. P. (2007). "GPIHBP1: An endothelial cell molecule important for the lipolytic processing of chylomicrons". Current Opinion in Lipidology. 18 (4): 389–396. doi:10.1097/MOL.0b013e3281527914. PMC 2888298. PMID 17620854.
  • Ruge, T.; Sukonina, V.; Kroupa, O.; Makoveichuk, E.; Lundgren, M.; Svensson, M. K.; Olivecrona, G.; Eriksson, J. W. (2012). "Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus". Metabolism. 61 (5): 652–660. doi:10.1016/j.metabol.2011.09.014. PMID 22078753.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e