INTS12

Protein-coding gene in the species Homo sapiens

INTS12

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1WEV

Identifiers

Aliases

INTS12, INT12, PHF22, SBBI22, integrator complex subunit 12

External IDs

OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[1]

Band	3\|3 G3	Start	132,797,601 bp^[1]
Band	3\|3 G3	End	132,816,749 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

right ventricle

islet of Langerhans

gastrocnemius muscle

jejunal mucosa

triceps brachii muscle

ganglionic eminence

biceps brachii

Achilles tendon

Top expressed in

secondary oocyte

genital tubercle

zygote

primary oocyte

tail of embryo

granulocyte

otic placode

medial ganglionic eminence

epiblast

maxillary prominence

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding metal ion binding
Cellular component	integrator complex nucleoplasm nucleus
Biological process	snRNA processing snRNA transcription by RNA polymerase II snRNA 3'-end processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57117


71793

Ensembl


n/a


ENSMUSG00000028016

UniProt


Q96CB8


Q9D168

RefSeq (mRNA)


NM_001142471 NM_020395


NM_027927

RefSeq (protein)


NP_001135943 NP_065128 NP_001135943.1 NP_065128.2


NP_082203

Location (UCSC)

n/a

Chr 3: 132.8 – 132.82 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.^[4]

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2)^[4]^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028016 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: integrator complex subunit 12". Retrieved 2011-08-30.
^ Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.