| # | Date | Film | Weekend Gross | Total Gross |
| 1 | January 3, 2010 | Sherlock Holmes | $6,582,433 | $26,955,437 |
| 2 | January 10, 2010 | Io, Loro e Lara | $6,753,283 | $21,347,896 |
| 3 | January 17, 2010 | Avatar | $13,889,941 | $83,498,193 |
| 4 | January 24, 2010 | Avatar | $12,383,549 | |
| 5 | January 31, 2010 | Avatar | $10,357,947 | |
| 6 | February 7, 2010 | Avatar | $7,783,01 | |
| 7 | February 14, 2010 | Avatar | $5,181,248 | |
| 8 | February 21, 2010 | Avatar | $3,767,803 | |
| 9 | February 28, 2010 | Genitori & figli. Agitare bene prima dell'uso | $3,802,776 | $11,455,266 |
| 10 | March 7, 2010 | Alice in Wonderland | $11,115,961 | $39,952,697 |
| 11 | March 14, 2010 | Alice in Wonderland | $8,311,436 | |
| 12 | March 21, 2010 | Alice in Wonderland | $4,307,666 | |
| 13 | March 28, 2010 | How to Train Your Dragon | $1,630,412 | $9,979,666 |
| 14 | April 4, 2010 | La vita è una cosa meravigliosa | $2,287,044 | $6,161,728 |
| 15 | April 11, 2010 | The Ghost Writer | $1,382,472 | $4,811,454 |
| 16 | April 18, 2010 | Clash of the Titans | $4,286,144 | $10,275,464 |
| 17 | April 25, 2010 | Clash of the Titans | $2,133,330 | |
| 18 | May 2, 2010 | Iron Man 2 | $4,701,280 | $9,979,666 |
| 19 | May 9, 2010 | Iron Man 2 | $2,073,896 | |
| 20 | May 16, 2010 | Robin Hood | $5,172,957 | $14,676,791 |
| 21 | May 23, 2010 | Prince of Persia: The Sands of Time | $1,909,536 | $8,912,558 |
| 22 | May 30, 2010 | Sex and the City 2 | $2,072,658 | $7,802,889 |
| 23 | June 6, 2010 | Sex and the City 2 | $896,600 | |
| 24 | June 13, 2010 | The Hole | $495,714 | $2,094,728 |
| 25 | June 20, 2010 | The A-Team | $1,111,167 | $3,143,928 |
| 26 | June 27, 2010 | The A-Team | $396,533 | |
| 27 | July 4, 2010 | The Twilight Saga: Eclipse | $4,793,904 | $20,711,944 |
| 28 | July 11, 2010 | Toy Story 3 | $3,021,009 | $18,855,881 |
| 29 | July 18, 2010 | Toy Story 3 | $2,011,511 | |
| 30 | July 25, 2010 | Toy Story 3 | $1,245,241 | |
| 31 | August 1, 2010 | Toy Story 3 | $838,708 | |
| 32 | August 8, 2010 | Toy Story 3 | $500,852 | |
| 33 | August 15, 2010 | Marmaduke | $940,960 | $2,503,450 |
| 34 | August 22, 2010 | The Sorcerer's Apprentice | $16,968,032 | $9,571,490 |
| 35 | August 29, 2010 | Shrek Forever After | $4,504,291 | $23,451,561 |
| 36 | September 5, 2010 | Shrek Forever After | $3,637,448 | |
| 37 | September 12, 2010 | Shrek Forever After | $1,915,433 | |
| 38 | September 19, 2010 | Vampires Suck | $2,483,735 | $6,000,711 |
| 39 | September 26, 2010 | Inception | $3,556,167 | $15,459,083 |
| 40 | October 3, 2010 | Benvenuti al Sud | $5,231,564 | $43,015,634 |
| 41 | October 10, 2010 | Benvenuti al Sud | $6,242,77 | |
| 42 | October 17, 2010 | Benvenuti al Sud | $5,528,640 | |
| 43 | October 24, 2010 | Benvenuti al Sud | $3,889,528 | |
| 44 | October 31, 2010 | Maschi contro femmine | $4,222,767 | $18,452,860 |
| 45 | November 7, 2010 | Maschi contro femmine | $3,582,226 | |
| 46 | November 14, 2010 | Maschi contro femmine | $1,869,690 | |
| 47 | November 21, 2010 | Harry Potter and the Deathly Hallows – Part 1 | $10,193,771 | $23,988,197 |
| 48 | November 28, 2010 | Harry Potter and the Deathly Hallows - Part 1 | $4,625,564 | |
| 49 | December 5, 2010 | Tangled | $2,710,588 | $14,670,362 |
| 50 | December 12, 2010 | Tangled | $1,918,925 | |
| 51 | December 19, 2010 | Natale in Sud Africa | $4,282,724 | $24,898,572 |
| 52 | December 26, 2010 | Natale in Sud Africa | $8,073,079 | |
| 53 | January 2, 2011 | La banda dei babbi natale | $5,763,680 | $29,125,119 |
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