MRGPRX2
MRGPRX2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607228; MGI: 3588270; HomoloGene: 24986; GeneCards: MRGPRX2; OMA:MRGPRX2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.[7]
Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183695 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074109 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
- ^ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".
- ^ a b Rich, Robert R.; Fleisher, Thomas A.; Schroeder, Harry W.; Weyand, Cornelia M.; Corry, David B.; Puck, Jennifer, eds. (2023). Clinical immunology: principles and practice (6th ed.). Amsterdam, The Netherlands: Elsevier. ISBN 978-0-7020-8165-1. OCLC 1295106160.
Further reading
- Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.
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