Moroxydine

Moroxydine
Names

IUPAC name N-(Diaminomethylidene)morpholine-4-carboximidamide
Other names Moroxidine
Identifiers
CAS Number	3731-59-7^Y
3D model (JSmol)	Interactive image
ChemSpider	64715^N
ECHA InfoCard	100.020.994
EC Number	223-093-1
KEGG	D07250^Y
PubChem CID	71655
UNII	O611591WAH^Y
CompTox Dashboard (EPA)	DTXSID3048526
InChI InChI=1S/C6H13N5O/c7-5(8)10-6(9)11-1-3-12-4-2-11/h1-4H2,(H5,7,8,9,10)^N Key: KJHOZAZQWVKILO-UHFFFAOYSA-N^N InChI=1/C6H13N5O/c7-5(8)10-6(9)11-1-3-12-4-2-11/h1-4H2,(H5,7,8,9,10) Key: KJHOZAZQWVKILO-UHFFFAOYAH
SMILES C1COCCN1C(=N)N=C(N)N
Properties
Chemical formula	C₆H₁₃N₅O
Molar mass	171.20 g/mol
Pharmacology
ATC code	J05AX01 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Chemical compound

Moroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses.^[1] Structurally moroxydine is a heterocyclic biguanidine.^{[citation needed]}

It was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings.^[2]

References

^ Sheppard, S. (1994). "Moroxydine: The story of a mislaid antiviral". Acta Dermato-Venereologica. Supplementum. 183: 1–9. PMID 9868507.
^ Moore, Malcolm (2014-03-20). "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20.

Wikispecies has information related to Moroxydine.

RNA virus antivirals (primarily J05, also S01AD and D06BB)

Hepatitis C

NS3/4A protease inhibitors (–previr)	Asunaprevir Boceprevir^‡ Ciluprevir^§ Danoprevir^† Faldaprevir^‡ Glecaprevir Grazoprevir Narlaprevir Paritaprevir Simeprevir Sovaprevir^† Telaprevir^‡ Vaniprevir Vedroprevir^§ Voxilaprevir
NS5A inhibitors (–asvir)	Coblopasvir Daclatasvir^# Elbasvir Ledipasvir Odalasvir^† Ombitasvir Pibrentasvir Ravidasvir^† Ruzasvir^† Samatasvir^† Velpatasvir
NS5B RNA polymerase inhibitors (–buvir)	Beclabuvir^† Bemnifosbuvir^† Dasabuvir^# Deleobuvir^§ Filibuvir^§ GS-6620^§ IDX-184^§ Setrobuvir^§ Sofosbuvir^# Tegobuvir^§ TMC-647055^§ Radalbuvir^† Uprifosbuvir^†
Combination drugs	Elbasvir/grazoprevir Glecaprevir/pibrentasvir Ledipasvir/sofosbuvir^# Ombitasvir/paritaprevir/ritonavir^# Sofosbuvir/daclatasvir Sofosbuvir/velpatasvir^# Sofosbuvir/velpatasvir/voxilaprevir

Hepatitis D

Bulevirtide

Picornavirus

viral entry: Pleconaril^†

Anti-influenza agents

neuraminidase inhibitors/release phase (Oseltamivir^#
Zanamivir
Peramivir, Laninamivir^†)

Multiple/general

Interferon	Interferon alfa 2b Peginterferon alfa-2a^# Peginterferon alfa-2b^#
3CL protease inhibitors (–trelvir)	Ensitrelvir^† Lufotrelvir Nirmatrelvir^† (+ritonavir)^† Rupintrivir Simnotrelvir (+ritonavir^†)
RNA pol inhibitors	CMX521^§ Deuremidevir^† Favipiravir Galidesivir^† GS-441524^§ Remdesivir MK-608^§ Mericitabine^† Molnupiravir NITD008^§ Ribavirin^# Taribavirin^† Triazavirin Valopicitabine^†
Multiple/Unknown/Other	EICAR^§ Merimepodib^§ Moroxydine Presatovir^†

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

DNA virus antivirals (primarily J05, also S01AD and D06BB)

Baltimore I

Herpesvirus

DNA-synthesis
inhibitor

TK activated

Purine analogue	guanine (Aciclovir^#/Valaciclovir Ganciclovir/Valganciclovir^# Penciclovir/Famciclovir) adenine (Vidarabine)
Pyrimidine analogue	uridine (Idoxuridine Trifluridine (+tipiracil) Edoxudine) thymine Brivudine FV-100^† Sorivudine^‡ cytosine (Cytarabine)

Not TK activated

Foscarnet

Other

HPV/MC

Vaccinia

assembly: Rifampicin

Poxviridae

Hepatitis B (VII)

Nucleoside analogues/NARTIs: Entecavir^#
Lamivudine
Lobucavir^†
Telbivudine
Clevudine

Multiple/general

Nucleic acid inhibitors	Cidofovir Brincidofovir
Interferon	Interferon alfa 2b Peginterferon alfa-2a
Multiple/unknown	Filociclovir^† Ribavirin^#/Taribavirin^† Moroxydine