NIP7

Protein-coding gene in humans
NIP7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1SQW, 1T5Y

Identifiers
AliasesNIP7, HSPC031, KD93, CGI-37, nucleolar pre-rRNA processing protein, nucleolar pre-rRNA processing protein NIP7
External IDsMGI: 1913414; HomoloGene: 56743; GeneCards: NIP7; OMA:NIP7 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NIP7
Genomic location for NIP7
Band16q22.1Start69,337,996 bp[1]
End69,343,106 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NIP7
Genomic location for NIP7
Band8|8 D3Start107,783,509 bp[2]
End107,787,563 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • mucosa of pharynx

  • oral cavity

  • gonad

  • islet of Langerhans

  • nipple

  • gums

  • superior surface of tongue

  • rectum

  • gingival epithelium
Top expressed in
  • endocardial cushion

  • somite

  • epiblast

  • primitive streak

  • mandibular prominence

  • maxillary prominence

  • abdominal wall

  • otic placode

  • embryo

  • migratory enteric neural crest cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • nucleus
  • nucleolus
  • preribosome, large subunit precursor
  • cytosol
Biological process
  • ribosome biogenesis
  • ribosome assembly
  • ribosomal large subunit biogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51388

66164

Ensembl

ENSG00000132603

ENSMUSG00000031917

UniProt

Q9Y221

Q9CXK8

RefSeq (mRNA)

NM_016101
NM_001199434

NM_001164472
NM_025391

RefSeq (protein)

NP_001186363
NP_057185

NP_001157944
NP_079667

Location (UCSC)Chr 16: 69.34 – 69.34 MbChr 8: 107.78 – 107.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosome subunit biogenesis protein NIP7 homolog is a protein that in humans is encoded by the NIP7 gene.[5][6]

Interactions

NIP7 has been shown to interact with NOL8.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132603 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031917 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J Biol Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
  6. ^ "Entrez Gene: NIP7 nuclear import 7 homolog (S. cerevisiae)".

Further reading

  • Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Liu JF, Wang XQ, Wang ZX, Chen JR, Jiang T, An XM, Chang WR, Liang DC (2005). "Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells". J. Struct. Biol. 148 (3): 370–4. doi:10.1016/j.jsb.2004.06.010. PMID 15522784.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • v
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  • e
  • 1sqw: Crystal structure of KD93, a novel protein expressed in the human pro
    1sqw: Crystal structure of KD93, a novel protein expressed in the human pro
  • 1t5y: Crystal Structure of Northeast Structural Genomics Consortium Target HR2118: A Human Homolog of Saccharomyces cerevisiae Nip7p
    1t5y: Crystal Structure of Northeast Structural Genomics Consortium Target HR2118: A Human Homolog of Saccharomyces cerevisiae Nip7p


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