NOS1AP

Protein-coding gene in the species Homo sapiens

NOS1AP

Identifiers

Aliases

NOS1AP, 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein, NPHS22

External IDs

OMIM: 605551 HomoloGene: 136252 GeneCards: NOS1AP

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q23.3	Start	162,069,691 bp^[1]
Band	1q23.3	End	162,370,475 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Region I of hippocampus proper

cerebellar vermis

frontal pole

orbitofrontal cortex

prefrontal cortex

superior frontal gyrus

Brodmann area 46

parietal lobe

Brodmann area 9

postcentral gyrus

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding nitric-oxide synthase binding
Cellular component	L-type voltage-gated calcium channel complex cytosol nuclear membrane inward rectifier potassium channel complex perinuclear region of cytoplasm sarcolemma nucleus mitochondrion caveola Z disc T-tubule sarcoplasmic reticulum membrane glutamatergic synapse
Biological process	positive regulation of peptidyl-cysteine S-nitrosylation regulation of cardiac muscle cell action potential positive regulation of nitric oxide biosynthetic process regulation of nitric-oxide synthase activity positive regulation of delayed rectifier potassium channel activity positive regulation of gene expression positive regulation of nitric oxide mediated signal transduction positive regulation of nitric-oxide synthase activity regulation of high voltage-gated calcium channel activity positive regulation of potassium ion transmembrane transport regulation of heart rate by chemical signal positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization regulation of nitric oxide biosynthetic process regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of ventricular cardiac muscle cell membrane repolarization postsynaptic actin cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9722


n/a

Ensembl


ENSG00000198929


n/a

UniProt


O75052


n/a

RefSeq (mRNA)


NM_014697 NM_001126060 NM_001164757


n/a

RefSeq (protein)


NP_001119532 NP_001158229 NP_055512


n/a

Location (UCSC)

Chr 1: 162.07 – 162.37 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.^[3]^[4]^[5]

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.^[5] NOS1AP polymorphisms has been associated with the QT interval length.^[6]

Interactions

NOS1AP has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (February 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. S2CID 263410587.
^ ^a ^b Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (Mar 1998). "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95". Neuron. 20 (1): 115–24. doi:10.1016/S0896-6273(00)80439-0. PMID 9459447. S2CID 14613261.
^ ^a ^b "Entrez Gene: NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein".
^ Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A (2006). "A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization". Nat. Genet. 38 (6): 644–51. doi:10.1038/ng1790. PMID 16648850. S2CID 12942685.
^ ^a ^b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
^ Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (October 2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron. 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993. S2CID 10533464.
^ Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH (March 2002). "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. Bibcode:2002PNAS...99.3199J. doi:10.1073/pnas.261705799. PMC 122496. PMID 11867766.