Oxantel

Chemical compound
  • P02CC02 (WHO) QP52AF03 (WHO)
Identifiers
  • 3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
CAS Number
  • 36531-26-7 checkY
PubChem CID
  • 5281087
ChemSpider
  • 4444540 ☒N
UNII
  • 94AJJ30D9E
KEGG
  • D00806 checkY
CompTox Dashboard (EPA)
  • DTXSID601016597 Edit this at Wikidata
Chemical and physical dataFormulaC13H16N2OMolar mass216.284 g·mol−13D model (JSmol)
  • Interactive image
  • CN1CCCN=C1/C=C/C2=CC(=CC=C2)O
InChI
  • InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+ ☒N
  • Key:VRYKTHBAWRESFI-VOTSOKGWSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms.[1] It has also been shown to inhibit fumarate reductase in some pathogenic bacteria.[2]

Similarly to pyrantel, oxantel depolarises the neurons of gastrointestinal parasites 100x more than acetylcholine, causing sustained muscular contraction, causing the parasites to die by spastic paralysis. This anthelmintic is commonly used to treat domestic animals as well as livestock, and resistance has been reported in both groups of animals.[3]

References

  1. ^ Palmeirim MS, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J (June 2021). "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review". Drugs. 81 (8): 907–921. doi:10.1007/s40265-021-01505-1. PMC 8144136. PMID 33929716.
  2. ^ Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, Walsh K, D'Cruze T, Hoffmann B, Catmull D, Zhu Y, Reynolds E (2014). "Oxantel disrupts polymicrobial biofilm development of periodontal pathogens". Antimicrobial Agents and Chemotherapy. 58 (1): 378–85. doi:10.1128/AAC.01375-13. PMC 3910723. PMID 24165189.
  3. ^ Kopp, Steven R.; Kotze, Andrew C.; McCarthy, James S.; Traub, Rebecca J.; Coleman, Glen T. (2008-11-01). "Pyrantel in small animal medicine: 30 years on". The Veterinary Journal. 178 (2): 177–184. doi:10.1016/j.tvjl.2007.06.021. ISSN 1090-0233.
  • v
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Antiparasitics – Anthelmintics (P02) and endectocides (QP54)
Antiplatyhelmintic agents
Antitrematodals
(schistosomicides)
Binds tubulin
AChE inhibitor
Other/unknown
Anticestodals
(taeniacides)
Binds tubulin
Other/unknown
Antinematodal agents
(including
macrofilaricides)
Binds tubulin
Glutamate-gated chloride channel, GABA receptor
NMDA
Other/unknown


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