PRKCG

Protein-coding gene in the species Homo sapiens
PRKCG
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E73, 2UZP

Identifiers
AliasesPRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma, PKCI(3), PKCgamma
External IDsOMIM: 176980; MGI: 97597; HomoloGene: 20602; GeneCards: PRKCG; OMA:PRKCG - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PRKCG
Genomic location for PRKCG
Band19q13.42Start53,879,190 bp[1]
End53,907,652 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PRKCG
Genomic location for PRKCG
Band7 A1|7 1.93 cMStart3,337,704 bp[2]
End3,379,615 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • nucleus accumbens

  • prefrontal cortex

  • amygdala

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • caudate nucleus

  • right hemisphere of cerebellum

  • hippocampus proper
Top expressed in
  • hippocampus proper

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellum

  • cerebellar cortex

  • Cortex of frontal lobe

  • superior frontal gyrus

  • striatum of neuraxis

  • hypothalamus

  • olfactory bulb
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • nucleotide binding
  • protein kinase C activity
  • zinc ion binding
  • metal ion binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein serine/threonine/tyrosine kinase activity
  • ATP binding
  • calcium-dependent protein kinase C activity
Cellular component
  • cytoplasm
  • synaptic membrane
  • cytosol
  • cell projection
  • membrane
  • cell-cell junction
  • plasma membrane
  • synapse
  • intracellular anatomical structure
  • cell junction
  • dendrite
  • perinuclear region of cytoplasm
  • neuron projection
  • nucleus
  • postsynaptic density
  • calyx of Held
  • presynaptic cytosol
  • postsynaptic cytosol
Biological process
  • negative regulation of neuron apoptotic process
  • intracellular signal transduction
  • phosphorylation
  • negative regulation of protein catabolic process
  • rhythmic process
  • regulation of response to food
  • platelet activation
  • chemosensory behavior
  • negative regulation of protein ubiquitination
  • protein phosphorylation
  • response to morphine
  • positive regulation of mismatch repair
  • response to pain
  • regulation of circadian rhythm
  • peptidyl-serine phosphorylation
  • learning or memory
  • protein autophosphorylation
  • negative regulation of proteasomal protein catabolic process
  • regulation of phagocytosis
  • innervation
  • chemical synaptic transmission
  • response to psychosocial stress
  • presynaptic modulation of chemical synaptic transmission
  • regulation of synaptic vesicle exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5582

18752

Ensembl

ENSG00000126583

ENSMUSG00000078816

UniProt

P05129

P63318

RefSeq (mRNA)

NM_002739
NM_001316329

NM_001291434
NM_011102

RefSeq (protein)

NP_001303258
NP_002730

NP_001278363
NP_035232

Location (UCSC)Chr 19: 53.88 – 53.91 MbChr 7: 3.34 – 3.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.[5][6]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).[7]

Interactions

PRKCG has been shown to interact with GRIA4.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126583 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078816 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
  6. ^ Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. Bibcode:1986Sci...233..859C. doi:10.1126/science.3755548. PMID 3755548.
  7. ^ "Entrez Gene: PRKCG protein kinase C, gamma".
  8. ^ Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. 278 (8). United States: 6307–13. doi:10.1074/jbc.M205587200. hdl:10316/12633. ISSN 0021-9258. PMID 12471040.

Further reading

  • Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
  • Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions". Chem. Phys. Lipids. 116 (1–2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536.
  • Saito N, Shirai Y (2003). "Protein kinase C gamma (PKC gamma): function of neuron specific isotype". J. Biochem. 132 (5): 683–7. doi:10.1093/oxfordjournals.jbchem.a003274. PMID 12417016.

External links

  • GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14
  • v
  • t
  • e
  • 1tbn: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    1tbn: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
  • 1tbo: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, 30 STRUCTURES
    1tbo: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, 30 STRUCTURES
  • 2uzp: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.
    2uzp: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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