Placenta specific 8

Protein-coding gene in the species Homo sapiens
PLAC8
Identifiers
AliasesPLAC8, C15, DGIC, onzin, PNAS-144, placenta specific 8, placenta associated 8
External IDsOMIM: 607515; MGI: 2445289; HomoloGene: 32328; GeneCards: PLAC8; OMA:PLAC8 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PLAC8
Genomic location for PLAC8
Band4q21.22Start83,090,048 bp[1]
End83,137,075 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for PLAC8
Genomic location for PLAC8
Band5 E4|5 48.49 cMStart100,701,591 bp[2]
End100,720,111 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • mucosa of transverse colon

  • mucosa of sigmoid colon

  • epithelium of nasopharynx

  • bone marrow

  • granulocyte

  • mucosa of ileum

  • trabecular bone

  • bone marrow cells

  • rectum
Top expressed in
  • gastrula

  • duodenum

  • mucous cell of stomach

  • jejunum

  • colon

  • left colon

  • pyloric antrum

  • decidua

  • tibiofemoral joint

  • ileum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • chromatin binding
Cellular component
  • extracellular region
  • azurophil granule lumen
Biological process
  • positive regulation of cell population proliferation
  • response to cold
  • negative regulation of multicellular organism growth
  • defense response to bacterium
  • negative regulation of apoptotic process
  • positive regulation of transcription by RNA polymerase II
  • brown fat cell differentiation
  • neutrophil degranulation
  • positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51316

231507

Ensembl

ENSG00000145287

ENSMUSG00000029322

UniProt

Q9NZF1

Q9JI48

RefSeq (mRNA)

NM_016619
NM_001130715
NM_001130716

NM_139198
NM_001370754

RefSeq (protein)

NP_001124187
NP_001124188
NP_057703

NP_631937
NP_001357683

Location (UCSC)Chr 4: 83.09 – 83.14 MbChr 5: 100.7 – 100.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Placenta specific 8 is a protein that in humans is encoded by the PLAC8 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145287 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029322 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Placenta specific 8". Retrieved 2017-12-22.

Further reading

  • Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ (2010). "The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation". Leukemia. 24 (3): 544–51. doi:10.1038/leu.2009.280. PMID 20072156. S2CID 205193718.
  • Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT (2013). "Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types". Curr Cancer Drug Targets. 13 (1): 80–91. doi:10.2174/156800913804486584. PMID 22920440.
  • Uehara H, Takahashi T, Izumi K (2013). "Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin". Int. J. Oncol. 43 (2): 365–74. doi:10.3892/ijo.2013.1954. PMC 3775580. PMID 23708710.
  • Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ (2014). "Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer". J. Clin. Invest. 124 (5): 2172–87. doi:10.1172/JCI71103. PMC 4001536. PMID 24691442.
  • Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H (2014). "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression". Cell Rep. 7 (4): 1143–55. doi:10.1016/j.celrep.2014.03.061. PMC 4112575. PMID 24794439.
  • Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, Gohn CR, Varberg KM, McClintick JN, Haneline LS (2015). "Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus". Diabetes. 64 (7): 2664–75. doi:10.2337/db14-1709. PMC 4477353. PMID 25720387.
  • Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M (2016). "PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways". Cancer Res. 76 (1): 96–107. doi:10.1158/0008-5472.CAN-15-0216. PMID 26669866.
  • Li M, Liu D, Wang L, Wang W, Wang A, Yao Y (2016). "Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation". Fertil. Steril. 106 (3): 781–789.e2. doi:10.1016/j.fertnstert.2016.05.018. PMID 27322877.


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