SSH1

Protein-coding gene in the species Homo sapiens
SSH1
Identifiers
AliasesSSH1, SSH1L, slingshot protein phosphatase 1
External IDsOMIM: 606778; MGI: 2686240; HomoloGene: 41299; GeneCards: SSH1; OMA:SSH1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SSH1
Genomic location for SSH1
Band12q24.11Start108,778,191 bp[1]
End108,857,590 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SSH1
Genomic location for SSH1
Band5|5 FStart114,075,155 bp[2]
End114,131,955 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • stromal cell of endometrium

  • saphenous vein

  • secondary oocyte

  • trigeminal ganglion

  • lower lobe of lung

  • lactiferous duct

  • tail of epididymis

  • spinal ganglia

  • caput epididymis
Top expressed in
  • internal carotid artery

  • Rostral migratory stream

  • external carotid artery

  • sciatic nerve

  • substantia nigra

  • fossa

  • blood

  • Gonadal ridge

  • ciliary body

  • cumulus cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphoprotein phosphatase activity
  • phosphatase activity
  • protein binding
  • protein tyrosine phosphatase activity
  • actin binding
  • hydrolase activity
  • protein tyrosine/serine/threonine phosphatase activity
Cellular component
  • cytoplasm
  • cell projection
  • plasma membrane
  • midbody
  • cleavage furrow
  • cytoskeleton
  • lamellipodium
  • cytosol
  • growth cone
  • cell leading edge
  • membrane
  • integral component of membrane
Biological process
  • regulation of lamellipodium assembly
  • protein dephosphorylation
  • regulation of axonogenesis
  • regulation of actin polymerization or depolymerization
  • cell morphogenesis
  • regulation of cellular protein metabolic process
  • peptidyl-tyrosine dephosphorylation
  • cellular response to ATP
  • actin cytoskeleton organization
  • dephosphorylation
  • positive regulation of synaptic plasticity
  • excitatory chemical synaptic transmission
  • positive regulation of neuron death
  • positive regulation of AMPA glutamate receptor clustering
  • positive regulation of vascular associated smooth muscle cell migration
  • positive regulation of excitatory postsynaptic potential
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54434

231637

Ensembl

ENSG00000084112

ENSMUSG00000042121

UniProt

Q8WYL5

Q76I79

RefSeq (mRNA)

NM_001161330
NM_001161331
NM_018984

NM_198109
NM_001363469

RefSeq (protein)

NP_001154802
NP_001154803
NP_061857

NP_932777
NP_001350398

Location (UCSC)Chr 12: 108.78 – 108.86 MbChr 5: 114.08 – 114.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

For the SSH-1 protocol, see Secure Shell#Version 1

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.[5][6][7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084112 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042121 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  6. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
  7. ^ a b "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Endo M, Ohashi K, Sasaki Y, et al. (2003). "Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin". J. Neurosci. 23 (7): 2527–37. doi:10.1523/JNEUROSCI.23-07-02527.2003. PMC 6742113. PMID 12684437.
  • Kaji N, Ohashi K, Shuin M, et al. (2003). "Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells". J. Biol. Chem. 278 (35): 33450–5. doi:10.1074/jbc.M305802200. PMID 12807904.
  • Ohta Y, Kousaka K, Nagata-Ohashi K, et al. (2004). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860. S2CID 24247372.
  • Nishita M, Wang Y, Tomizawa C, et al. (2004). "Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion". J. Biol. Chem. 279 (8): 7193–8. doi:10.1074/jbc.M312591200. PMID 14645219.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Dai S, Sarmiere PD, Wiggan O, et al. (2004). "Efficient Salmonella entry requires activity cycles of host ADF and cofilin". Cell. Microbiol. 6 (5): 459–71. doi:10.1111/j.1462-5822.2004.00375.x. PMID 15056216. S2CID 20238982.
  • Nagata-Ohashi K, Ohta Y, Goto K, et al. (2004). "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia". J. Cell Biol. 165 (4): 465–71. doi:10.1083/jcb.200401136. PMC 2172350. PMID 15159416.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Zhang Z, Niu Z, Yuan W, et al. (2005). "Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis". Hum. Mutat. 24 (5): 438. doi:10.1002/humu.9283. PMID 15459975. S2CID 22946257.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Soosairajah J, Maiti S, Wiggan O, et al. (2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
  • Wang Y, Shibasaki F, Mizuno K (2005). "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin". J. Biol. Chem. 280 (13): 12683–9. doi:10.1074/jbc.M411494200. PMID 15671020.
  • Nishita M, Tomizawa C, Yamamoto M, et al. (2006). "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration". J. Cell Biol. 171 (2): 349–59. doi:10.1083/jcb.200504029. PMC 2171197. PMID 16230460.
  • Yamamoto M, Nagata-Ohashi K, Ohta Y, et al. (2006). "Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L". FEBS Lett. 580 (7): 1789–94. doi:10.1016/j.febslet.2006.02.034. PMID 16513117. S2CID 27347823.
  • Cai L, Marshall TW, Uetrecht AC, et al. (2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC 2630706. PMID 17350576.
  • Kligys K, Claiborne JN, DeBiase PJ, et al. (2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". J. Biol. Chem. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
  • v
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Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class IIClass IIIClass IV
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