Suxibuzone
Analgesic drug used for joint and muscular pain
- M02AA22 (WHO) QM01AA90 (WHO)
- 4-[ [4-butyl-3,5-dioxo-1,2-di(phenyl)pyrazolidin-4-yl]methoxy]-4-oxobutanoic acid
- 27470-51-5 Y
- 5362
- 5169 N
- 86TDZ5WP2B
- D01289 Y
- ChEMBL1414320 N
- DTXSID6021296
- Interactive image
- O=C(O)CCC(=O)OCC2(C(=O)N(c1ccccc1)N(C2=O)c3ccccc3)CCCC
InChI
- InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28) N
- Key:ONWXNHPOAGOMTG-UHFFFAOYSA-N N
Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone,[1] and is commonly used in horses.[2]
References
- ^ Yasuda Y, Shindo T, Mitani N, Ishida N, Oono F, Kageyama T (1982). "Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans". Journal of Pharmaceutical Sciences. 71 (5): 565–72. doi:10.1002/jps.2600710521. PMID 7097505.
- ^ Sabaté D, Homedes J, Salichs M, Sust M, Monreal L (2009). "Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses". Equine Veterinary Journal. 41 (7): 700–5. doi:10.2746/042516409X464807. PMID 19927590.
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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