TFIP11

Protein-coding gene in the species Homo sapiens
TFIP11
Identifiers
AliasesTFIP11, NTR1, Spp382, TIP39, bK445C9.6, hNtr1, tuftelin interacting protein 11, STIP, STIP-1
External IDsOMIM: 612747; MGI: 1930075; HomoloGene: 40813; GeneCards: TFIP11; OMA:TFIP11 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TFIP11
Genomic location for TFIP11
Band22q12.1Start26,491,225 bp[1]
End26,512,505 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for TFIP11
Genomic location for TFIP11
Band5|5 FStart112,474,224 bp[2]
End112,485,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • muscle of thigh

  • gastrocnemius muscle

  • apex of heart

  • testicle

  • tendon of biceps brachii

  • sural nerve

  • left testis

  • Achilles tendon

  • right testis
Top expressed in
  • superior surface of tongue

  • gallbladder

  • granulocyte

  • Rostral migratory stream

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • epiblast

  • ventricular zone

  • yolk sac
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
Cellular component
  • cytoplasm
  • nuclear speck
  • catalytic step 2 spliceosome
  • U2-type post-mRNA release spliceosomal complex
  • nucleolus
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • extracellular matrix
Biological process
  • RNA processing
  • protection from non-homologous end joining at telomere
  • negative regulation of protein-containing complex assembly
  • biomineral tissue development
  • mRNA processing
  • spliceosomal complex disassembly
  • negative regulation of protein binding
  • negative regulation of double-strand break repair via nonhomologous end joining
  • RNA splicing
  • negative regulation of DNA ligase activity
  • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

24144

54723

Ensembl

ENSG00000100109

ENSMUSG00000029345

UniProt

Q9UBB9

Q9ERA6

RefSeq (mRNA)
NM_001008697
NM_001346857
NM_001346858
NM_001346859
NM_001346861

NM_001346862
NM_012143

NM_018783

RefSeq (protein)
NP_001008697
NP_001333786
NP_001333787
NP_001333788
NP_001333790

NP_001333791
NP_036275

NP_061253

Location (UCSC)Chr 22: 26.49 – 26.51 MbChr 5: 112.47 – 112.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tuftelin-interacting protein 11 is a protein that in humans is encoded by the TFIP11 gene.[5][6][7]


Interactions

TFIP11 has been shown to interact with Tuftelin.[5]{

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100109 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029345 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML (Aug 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J Biol Chem. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. PMID 10806191.
  6. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. ^ "Entrez Gene: TFIP11 tuftelin interacting protein 11".

Further reading

  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Wen X, Lei YP, Zhou YL, et al. (2005). "Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11)". Cell. Mol. Life Sci. 62 (9): 1038–46. doi:10.1007/s00018-005-4547-z. PMID 15868102. S2CID 11241573.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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