TNIP2

Protein-coding gene in the species Homo sapiens

TNIP2

Identifiers

Aliases

TNIP2, ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2

External IDs

OMIM: 610669; MGI: 2386643; HomoloGene: 11515; GeneCards: TNIP2; OMA:TNIP2 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p16.3	Start	2,741,648 bp^[1]
Band	4p16.3	End	2,756,342 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 B2	Start	34,653,431 bp^[2]
Band	5\|5 B2	End	34,671,335 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

pancreatic ductal cell

granulocyte

mucosa of transverse colon

apex of heart

gastric mucosa

muscle layer of sigmoid colon

body of stomach

upper lobe of left lung

monocyte

Top expressed in

neural layer of retina

interventricular septum

granulocyte

right kidney

primary visual cortex

muscle of thigh

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

esophagus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding protein kinase binding metal ion binding polyubiquitin modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding
Cellular component	nucleus cytosol cytoplasm nucleoplasm
Biological process	negative regulation of endothelial cell apoptotic process regulation of transcription, DNA-templated CD40 signaling pathway protein stabilization positive regulation of macrophage activation transcription, DNA-templated stress-activated MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II apoptotic process toll-like receptor 9 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway protein deubiquitination cellular response to lipopolysaccharide interleukin-1-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79155


231130

Ensembl


ENSG00000168884


ENSMUSG00000059866

UniProt


Q8NFZ5


Q99JG7

RefSeq (mRNA)


NM_024309 NM_001161527 NM_001292016


NM_139064

RefSeq (protein)


NP_001154999 NP_001278945 NP_077285


NP_620703

Location (UCSC)

Chr 4: 2.74 – 2.76 Mb

Chr 5: 34.65 – 34.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.^[5]^[6]^[7] TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
^ Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.
^ "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".
^ "TNIP2 (human)". www.phosphosite.org. Retrieved 2020-10-31.

Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC 2133159. PMID 10385526.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905. S2CID 32414520.
Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760. S2CID 202644741.
Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. hdl:2381/866. PMID 12609966.
Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905. S2CID 31400521.
Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. Bibcode:2007JRadR..48...13L. doi:10.1269/jrr.0615. PMID 17038805.