Xylosyltransferase

Class of enzymes

Xylosyltransferase are transferase enzymes which act upon xylose and are classified under EC 2.4.2.^[1]^[2]

More specifically, they can refer to:

Dolichyl-phosphate D-xylosyltransferase
Dolichyl-xylosyl-phosphate-protein xylosyltransferase
Flavonol-3-O-glycoside xylosyltransferase
Glycoprotein 2-beta-D-xylosyltransferase
Protein xylosyltransferase
Xyloglucan 6-xylosyltransferase
XYLT1
XYLT2
Zeatin O-beta-D-xylosyltransferase

References

^ Götting, Christian; Kuhn, Joachim; Weilke, Christian; Brinkmann, Thomas; Kleesiek, Knut; Sollberg, Stephan; Huerkamp, Christina; Krieg, Thomas (June 1999). "Serum Xylosyltransferase: a New Biochemical Marker of the Sclerotic Process in Systemic Sclerosis". Journal of Investigative Dermatology. 112 (6): 919–924. doi:10.1046/j.1523-1747.1999.00590.x. ISSN 0022-202X.
^ Poönighaus, Claudia; Ambrosius, Michael; Casanova, Javier Carrera; Prante, Christian; Kuhn, Joachim; Esko, Jeffrey D.; Kleesiek, Knut; Goötting, Christian (February 2007). "Human Xylosyltransferase II Is Involved in the Biosynthesis of the Uniform Tetrasaccharide Linkage Region in Chondroitin Sulfate and Heparan Sulfate Proteoglycans". Journal of Biological Chemistry. 282 (8): 5201–5206. doi:10.1074/jbc.m611665200. ISSN 0021-9258.

Transferases: glycosyltransferases (EC 2.4)

2.4.1: Hexosyl-
transferases

Glucosyl-	Phosphorylase Starch Glycogen Cellobiose Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-Beta-glucan synthase Ceramide glucosyltransferase N-glycosyltransferase
Galactosyl-	Lactose synthase B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
Glucuronosyl-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hyaluronan synthase: HAS1 HAS2 HAS3
Fucosyl-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Mannosyl-	Dolichyl-phosphate-mannose-protein mannosyltransferase POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentosyl-
transferases

Ribose

ADP-ribosyltransferase	NAD⁺:diphthamide ADP-ribosyltransferase Diphtheria toxin Pseudomonas exotoxin NAD(P)⁺:arginine ADP-ribosyltransferase Pertussis toxin Cholera toxin Poly ADP ribose polymerase Sirtuin
Phosphoribosyltransferase	Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Uracil phosphoribosyltransferase Amidophosphoribosyltransferase
Other	Purine nucleoside phosphorylase: Thymidine phosphorylase ECGF1

Other

Xylosyltransferase
- XYLT1
- XYLT2
Arabinosyltransferase
- Indolylacetylinositol arabinosyltransferase

2.4.99: Sialyl
transferases

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

xylosyl transferase is the first enzyme involved in the biosynthesis of glycosaminoglycan chains, an important constituent of proteoglycans. There are two types of xylosyl transferases type I and type II.

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