ZFYVE26

Protein-coding gene in the species Homo sapiens

ZFYVE26

Identifiers

Aliases

ZFYVE26, FYVE-CENT, SPG15, zinc finger FYVE-type containing 26

External IDs

OMIM: 612012; MGI: 1924767; HomoloGene: 9102; GeneCards: ZFYVE26; OMA:ZFYVE26 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.1	Start	67,727,374 bp^[1]
Band	14q24.1	End	67,816,590 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C3	Start	79,279,120 bp^[2]
Band	12\|12 C3	End	79,343,078 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

endothelial cell

visceral pleura

Skeletal muscle tissue of biceps brachii

internal globus pallidus

tendon of biceps brachii

muscle of thigh

epithelium of colon

stromal cell of endometrium

ventricular zone

Top expressed in

granulocyte

zygote

genital tubercle

epithelium of small intestine

neural layer of retina

blastocyst

left lobe of liver

tail of embryo

spermatocyte

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding metal ion binding lipid binding phosphatidylinositol-3-phosphate binding
Cellular component	cytoplasm lysosomal membrane centrosome cytoskeleton microtubule organizing center midbody
Biological process	cell division cell cycle cytokinesis double-strand break repair via homologous recombination DNA repair cellular response to DNA damage stimulus mitotic cytokinesis regulation of cytokinesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23503


211978

Ensembl


ENSG00000072121


ENSMUSG00000066440

UniProt


Q68DK2


Q5DU37

RefSeq (mRNA)


NM_015346


NM_001008550

RefSeq (protein)


NP_056161


NP_001008550

Location (UCSC)

Chr 14: 67.73 – 67.82 Mb

Chr 12: 79.28 – 79.34 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene.^[5]

Function

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066440 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Zinc finger, FYVE domain containing 26".

Elleuch N, Bouslam N, Hanein S, Lossos A, Hamri A, Klebe S, Meiner V, Birouk N, Lerer I, Grid D, Bacq D, Tazir M, Zelenika D, Argov Z, Durr A, Yahyaoui M, Benomar A, Brice A, Stevanin G (Nov 2007). "Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families". Neurogenetics. 8 (4): 307–15. doi:10.1007/s10048-007-0097-x. PMID 17661097. S2CID 25209385.
Boukhris A, Stevanin G, Feki I, Denis E, Elleuch N, Miladi MI, Truchetto J, Denora P, Belal S, Mhiri C, Brice A (Mar 2008). "Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity". Archives of Neurology. 65 (3): 393–402. doi:10.1001/archneur.65.3.393. PMID 18332254.
Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011). "A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis". PLOS ONE. 6 (3): e17086. Bibcode:2011PLoSO...617086S. doi:10.1371/journal.pone.0017086. PMC 3063775. PMID 21455500.
Goizet C, Boukhris A, Maltete D, Guyant-Maréchal L, Truchetto J, Mundwiller E, Hanein S, Jonveaux P, Roelens F, Loureiro J, Godet E, Forlani S, Melki J, Auer-Grumbach M, Fernandez JC, Martin-Hardy P, Sibon I, Sole G, Orignac I, Mhiri C, Coutinho P, Durr A, Brice A, Stevanin G (Oct 2009). "SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum". Neurology. 73 (14): 1111–9. doi:10.1212/WNL.0b013e3181bacf59. PMID 19805727. S2CID 39444163.
Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (Apr 2010). "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody" (PDF). Nature Cell Biology. 12 (4): 362–71. doi:10.1038/ncb2036. hdl:10852/28044. PMID 20208530. S2CID 2765716.
Schüle R, Schlipf N, Synofzik M, Klebe S, Klimpe S, Hehr U, Winner B, Lindig T, Dotzer A, Riess O, Winkler J, Schöls L, Bauer P (Dec 2009). "Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia". Journal of Neurology, Neurosurgery, and Psychiatry. 80 (12): 1402–4. doi:10.1136/jnnp.2008.167528. PMID 19917823. S2CID 23251702.
Murmu RP, Martin E, Rastetter A, Esteves T, Muriel MP, El Hachimi KH, Denora PS, Dauphin A, Fernandez JC, Duyckaerts C, Brice A, Darios F, Stevanin G (Jul 2011). "Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia". Molecular and Cellular Neurosciences. 47 (3): 191–202. doi:10.1016/j.mcn.2011.04.004. PMID 21545838. S2CID 5450391.
Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, Benomar A, Lossos A, Denora P, Fernandez J, Elleuch N, Forlani S, Durr A, Feki I, Hutchinson M, Santorelli FM, Mhiri C, Brice A, Stevanin G (Apr 2008). "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome". American Journal of Human Genetics. 82 (4): 992–1002. doi:10.1016/j.ajhg.2008.03.004. PMC 2427184. PMID 18394578.
Hughes CA, Byrne PC, Webb S, McMonagle P, Patterson V, Hutchinson M, Parfrey NA (May 2001). "SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q". Neurology. 56 (9): 1230–3. doi:10.1212/wnl.56.9.1230. PMID 11342696. S2CID 31185837.