Elastaza

Model elastaze.
Kristali svinjske elastaze.

U molekularnoj biologiji, elastaza je enzim iz klase proteaza (peptidaza) koje razlažu proteine.[1]

Forme i klasifikacija

Postoji osam ljudskih gena za elastaze:

Familija Simbol gena Ime proteina EC broj
Odobreno Prethodno Odobreno Prethodno
himotripsinu-
slična 		CELA1 ELA1 himotripsinu-slična familija elastaza, član 1 elastaza 1, pankreasna EC 3.4.21.36
CELA2A ELA2A himotripsinu-slična familija elastaza, član 2A elastaza 2A, pankreasna EC 3.4.21.71
CELA2B ELA2B himotripsinu-slična familija elastaza, član 2B elastaza 2B, pankreasna EC 3.4.21.71
CELA3A ELA3A himotripsinu-slična familija elastaza, član 3A elastaza 3A, pankreasna EC 3.4.21.70
CELA3B ELA3B himotripsinu-slična familija elastaza, član 3B elastaza 3B, pankreasna EC 3.4.21.70
himotripsin CTRC ELA4 himotripsin C (kaldekrin) elastaza 4 EC 3.4.21.2
neutrofil ELANE ELA2 neutrofilna elastaza elastaza 2 EC 3.4.21.37
makrofag MMP12 HME makrofagna metaloelastaza makrofagna elastaza EC 3.4.24.65

Bakterijske forme: Organizmi poput P. aeruginosa takođe formiraju elastate, i one se smatraju faktorom virulencije.

Reference

  1. ↑ Bieth JG (2001). „[The elastases]” (French). J. Soc. Biol. 195 (2): 173–9. PMID 11723830. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vidi još

Spoljašnje veze

  • GeneReviews/NCBI/NIH/UW entry on ELANE-Related Neutropenias including cyclic neutropenia
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TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6