RFC4

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Replikacioni faktor C (aktivator 1) 4, 37kDa
Identifikatori
SimboliRFC4; A1; RFC37
Vanjski IDOMIM: 102577 MGI: 2146571 HomoloGene: 6288 GeneCards: RFC4 Gene
Ontologija gena
Molekulska funkcija • DNK vezivanje
• proteinsko vezivanje
• ATP vezivanje
Ćelijska komponenta • nukleoplazma
• kompleks DNK replikacionog faktora C
Biološki proces • kontrolno mesto ćelijskog ciklusa
• S faza mitotičkog ćelijskog ciklusa
• mitotički ćelijski ciklus
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez5984106344
EnsemblENSG00000163918ENSMUSG00000022881
UniProtP35249Q99J62
Ref. Sekv. (iRNK)NM_002916NM_145480
Ref. Sekv. (protein)NP_002907NP_663455
Lokacija (UCSC)Chr 3:
186.51 - 186.52 Mb		Chr 16:
23.11 - 23.13 Mb
PubMed pretraga[1][2]

Replikacioni faktor C, podjedinica 4 je protein koji je kod ljudi kodiran RFC4 genom.[1][2]

Za elongaciju prajmiranog DNK šablona DNK polimerazom delta i DNK polimerazom epsilon neophodni su pomoćni proteini: proliferativni ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 140, 40, 38, 37, i 36 kDa. Ova podjedinica formira sržni kompleks sa 36 i 40 kDa podjedinicama. Kompleks manifestuje DNK zavisno ATPazno dejstvo, koje može da stimuliše PCNA u in vitro sistemima. Poznate su alternativno splajsovane transcriptne varijante koje kodiraju različite izoforme.[2]

Interakcije

RFC4 formira interakcije sa BRD4,[3] RFC2,[4][5] RFC3,[6][7] CHTF18,[8] PCNA[4][9] i RFC5.[4][5][6][10]

Reference

  1. ↑ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K, et al. (Jul 1995). „Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23”. Genomics 25 (1): 274–8. DOI:10.1016/0888-7543(95)80135-9. PMID 7774928. 
  2. ↑ 2,0 2,1 „Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa”. 
  3. ↑ Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. (United States) 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. ISSN 0270-7306. PMC 135621. PMID 12192049. 
  4. ↑ 4,0 4,1 4,2 Cai, J; Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. (UNITED STATES) 272 (30): 18974–81. DOI:10.1074/jbc.272.30.18974. ISSN 0021-9258. PMID 9228079. 
  5. ↑ 5,0 5,1 Cai, J; Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). „ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11607–12. DOI:10.1073/pnas.95.20.11607. ISSN 0027-8424. PMC 21688. PMID 9751713. 
  6. ↑ 6,0 6,1 Ellison, V; Stillman B (Mar 1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. ISSN 0021-9258. PMID 9488738. 
  7. ↑ Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. ISSN 0027-8424. PMC 39056. PMID 8692848. 
  8. ↑ Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep 2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. DOI:10.1073/pnas.1434308100. ISSN 0027-8424. PMC 193545. PMID 12930902. 
  9. ↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. (United States) 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 
  10. ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 

Literatura

  • Chen M, Pan ZQ, Hurwitz J (1992). „Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells”. Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5211–5. DOI:10.1073/pnas.89.12.5211. PMC 49261. PMID 1351677. 
  • Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848. 
  • Cujec TP, Cho H, Maldonado E, et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429. 
  • Cai J, Gibbs E, Uhlmann F, et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. 272 (30): 18974–81. DOI:10.1074/jbc.272.30.18974. PMID 9228079. 
  • Loor G, Zhang SJ, Zhang P, et al. (1998). „Identification of DNA replication and cell cycle proteins that interact with PCNA”. Nucleic Acids Res. 25 (24): 5041–6. DOI:10.1093/nar/25.24.5041. PMC 147130. PMID 9396813. 
  • Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. PMID 9488738. 
  • Zhang G, Gibbs E, Kelman Z, et al. (1999). „Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. DOI:10.1073/pnas.96.5.1869. PMC 26703. PMID 10051561. 
  • Uchiumi F, Watanabe M, Tanuma S (1999). „Characterization of telomere-binding activity of replication factor C large subunit p140”. Biochem. Biophys. Res. Commun. 258 (2): 482–9. DOI:10.1006/bbrc.1999.0589. PMID 10329413. 
  • van der Kuip H, Carius B, Haque SJ, et al. (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386–92. DOI:10.1007/s001090050365. PMID 10353443. 
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  • Naiki T, Kondo T, Nakada D, et al. (2001). „Chl12 (Ctf18) Forms a Novel Replication Factor C-Related Complex and Functions Redundantly with Rad24 in the DNA Replication Checkpoint Pathway”. Mol. Cell. Biol. 21 (17): 5838–45. DOI:10.1128/MCB.21.17.5838-5845.2001. PMC 87303. PMID 11486023. 
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  • Griffith JD, Lindsey-Boltz LA, Sancar A (2002). „Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy”. J. Biol. Chem. 277 (18): 15233–6. DOI:10.1074/jbc.C200129200. PMID 11907025. 
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  • Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929. 
  • Maruyama T, Farina A, Dey A, et al. (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Anderson LA, Perkins ND (2003). „Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C”. Mol. Cell. Biol. 23 (2): 721–32. DOI:10.1128/MCB.23.2.721-732.2003. PMC 151544. PMID 12509469. 
  • Nagata T, Takahashi Y, Ishii Y, et al. (2004). „Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array”. Int. J. Mol. Med. 11 (6): 713–21. DOI:10.3892/ijmm.11.6.713. PMID 12736711.