Klindamicin
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| Klinički podaci | |
|---|---|
| Prodajno ime | Chlolincocin, Cleocin, Cleocin Hcl, Cleocin Pediatric |
| Drugs.com | Monografija |
| Način primene | Oralno, Intravaginalnono, topikalno, intramaskularno, intravenozno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 2,4 h |
| Izlučivanje | Urinom |
| Identifikatori | |
| CAS broj | 18323-44-9  Y |
| ATC kod | D10AF01 (WHO), J01FF01 |
| PubChem | CID 29029 |
| DrugBank | DB01190 Y |
| ChemSpider | 27005 Y |
| KEGG | C06914 Y |
| ChEBI | CHEBI:3745 Y |
| ChEMBL | CHEMBL187 Y |
| Hemijski podaci | |
| Formula | C18H33ClN2O5S |
| Molarna masa | 424,983 |
SMILES
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InChI
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| Fizički podaci | |
| Tačka topljenja | 142 °C (288 °F) |
Klindamicin je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 424,983 Da.[1][2][3][4][5][6]
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 7 |
| Broj donora vodonika | 4 |
| Broj rotacionih veza | 7 |
| Particioni koeficijent[7] (ALogP) | 1,3 |
| Rastvorljivost[8] (logS, log(mol/L)) | -3,5 |
| Polarna površina[9] (PSA, Å2) | 127,6 |
Reference
- ^ Daum RS: Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med. 2007 Jul 26;357(4):380-90. PMID 17652653
- ^ Klempner MS, Styrt B: Clindamycin uptake by human neutrophils. J Infect Dis. 1981 Nov;144(5):472-9. PMID 6171600
- ^ Lamont RF: Can antibiotics prevent preterm birth--the pro and con debate. BJOG. 2005 Mar;112 Suppl 1:67-73. PMID 15715599
- ^ Plaisance KI, Drusano GL, Forrest A, Townsend RJ, Standiford HC: Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate. Antimicrob Agents Chemother. 1989 May;33(5):618-20. PMID 2751277
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди - ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Clindamycin
- p
- r
- u
| Aminoglikozidi (Inhibitori inicijacija) |
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|---|---|---|---|---|---|
| Tetraciklinski antibiotici (tRNK vezivanje) |
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| Steroidni antibiotici |
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 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Klindamicin na srodnim projektima Vikipedije:
Mediji na Ostavi
Podaci na Vikipodacima
