| IL18 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU | | |
| Ідентифікатори |
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| Символи | IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18 |
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| Зовнішні ІД | OMIM: 600953 MGI: 107936 HomoloGene: 1200 GeneCards: IL18 |
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| Онтологія гена |
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| Молекулярна функція | • GO:0001948, GO:0016582 protein binding
• cytokine activity
• interleukin-18 receptor binding
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| Клітинна компонента | • гіалоплазма
• extracellular region
• міжклітинний простір
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| Біологічний процес | • positive regulation of inflammatory response
• cell-cell signaling
• GO:1904579 cellular response to organic cyclic compound
• type 2 immune response
• MAPK cascade
• positive regulation of natural killer cell proliferation
• сон
• regulation of cell adhesion
• positive regulation of NK T cell proliferation
• positive regulation of granulocyte macrophage colony-stimulating factor production
• positive regulation of tissue remodeling
• Ангіогенез
• T-helper 1 type immune response
• positive regulation of interleukin-17 production
• inflammatory response
• lipopolysaccharide-mediated signaling pathway
• positive regulation of activated T cell proliferation
• positive regulation of protein kinase B signaling
• positive regulation of phosphatidylinositol 3-kinase signaling
• positive regulation of smooth muscle cell proliferation
• activation of protein kinase B activity
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• positive regulation of tyrosine phosphorylation of STAT protein
• GO:1901313 positive regulation of gene expression
• positive regulation of macrophage derived foam cell differentiation
• natural killer cell activation
• positive regulation of interferon-gamma production
• cholesterol homeostasis
• positive regulation of T-helper 2 cell differentiation
• negative regulation of myoblast differentiation
• triglyceride homeostasis
• проліферація
• regulation of signaling receptor activity
• interleukin-6 production
• T-helper 1 cell cytokine production
• neutrophil activation
• natural killer cell mediated cytotoxicity
• cytokine-mediated signaling pathway
• interleukin-18-mediated signaling pathway
• positive regulation of NIK/NF-kappaB signaling
• GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь
• positive regulation of NF-kappaB transcription factor activity
• positive regulation of T-helper 1 cell cytokine production
• positive regulation of cold-induced thermogenesis
• positive regulation of neuroinflammatory response
• GO:0072468 сигнальна трансдукція
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001243211
NM_001562
NM_001386420 |
| | NM_008360
NM_001357221
NM_001357222 |
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| RefSeq (білок) | | NP_001230140
NP_001553
NP_001230140.1 |
| | NP_032386
NP_001344150
NP_001344151 |
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| Локус (UCSC) | Хр. 11: 112.14 – 112.16 Mb | Хр. 9: 50.47 – 50.49 Mb |
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| PubMed search | [1] | [2] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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