钙蛋白酶9
| 钙蛋白酶9 | |||||||||||||||||||||||||
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| 識別號 | |||||||||||||||||||||||||
| 别名 | CAPN9；, GC36, nCL-4, calpain 9 | ||||||||||||||||||||||||
| 外部ID | OMIM：606401 MGI：1920897 HomoloGene：38208 GeneCards：CAPN9 | ||||||||||||||||||||||||
| 相關疾病 | |||||||||||||||||||||||||
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| 物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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| 蛋白序列 |
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| 基因位置（UCSC） | Chr 1: 230.75 – 230.8 Mb | Chr 8: 125.3 – 125.35 Mb | |||||||||||||||||||||||
| PubMed查找 | [4] | [5] | |||||||||||||||||||||||
| 維基數據 | |||||||||||||||||||||||||
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钙蛋白酶9（英语：Calpain-9）是一种在人类中由CAPN9基因编码的蛋白质。[6][7][8]
钙蛋白酶是普遍存在的、保守的钙依赖性半胱氨酸蛋白酶家族。钙蛋白酶是由不变的小亚基和可变的大亚基组成的异二聚体。大亚基具有半胱氨酸蛋白酶结构域，而两个亚基都具有钙结合结构域。钙蛋白酶与神经退行性过程有关，因为它们的激活可以由钙流入和氧化应激触发。由该基因编码的蛋白质主要在胃和小肠中表达，并可能在消化道中具有特殊功能。该基因被认为与胃癌有关。该基因可编码不同亚型的多个可变剪接转录物变体。[8]
参考资料
- ^ 與钙蛋白酶9相關的疾病；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000135773 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000031981 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.
- ^ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377
. PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x. - ^ 8.0 8.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始内容存档于2010-12-05）.
延伸阅读
- Huang Y, Wang KK. The calpain family and human disease. Trends in Molecular Medicine. 2001, 7 (8): 355–362. PMID 11516996. doi:10.1016/S1471-4914(01)02049-4.
- Suzuki K, Sorimachi H, Yoshizawa T, et al. Calpain: novel family members, activation, and physiologic function. Biol. Chem. Hoppe-Seyler. 1996, 376 (9): 523–9. PMID 8561910. doi:10.1515/bchm3.1995.376.9.523.
- Davis TL, Walker JR, Finerty PJ, et al. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J. Mol. Biol. 2007, 366 (1): 216–229. PMID 17157313. doi:10.1016/j.jmb.2006.11.037.
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
- Lee HJ, Tomioka S, Kinbara K, et al. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch. Biochem. Biophys. 1999, 362 (1): 22–31. PMID 9917325. doi:10.1006/abbi.1998.1021.
外部链接
- Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
- The MEROPS online database for peptidases and their inhibitors: C02.006
- PDB中UniProt可用的所有結構信息之概述：O14815 (Human Calpain-9 (CAPN9)) 在PDBe-KB（英语：PDBe-KB）。
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