| CD61 |
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| 已知的結構 |
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| PDB | 直系同源搜索: PDBe RCSB |
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| PDBID列表 |
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4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N |
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| 識別號 |
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| 别名 | ITGB3；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2 |
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| 外部ID | OMIM：173470 MGI：96612 HomoloGene：55444 GeneCards：ITGB3 |
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| 相關疾病 |
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| 血小板无力症、platelet-type bleeding disorder 16[1] |
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| 為以下藥物的標靶 |
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| cilengitide、依非巴特、tirofiban hydrochloride hydrate[2] |
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| RNA表达模式 |
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| 查阅更多表达数据 |
| 基因本體 |
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| 分子功能 | • vascular endothelial growth factor receptor 2 binding
• fibronectin binding
• virus receptor activity
• extracellular matrix binding
• protein disulfide isomerase activity
• 蛋白酶結合
• platelet-derived growth factor receptor binding
• 血浆蛋白结合
• 相同蛋白质结合
• 酶结合
• cell adhesion molecule binding
• neuregulin binding
• coreceptor activity
• fibroblast growth factor binding
• insulin-like growth factor I binding
• C-X3-C chemokine binding
• integrin binding
• fibrinogen binding
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| 細胞組分 | • integral component of membrane
• cell projection
• alphav-beta3 integrin-vitronectin complex
• 膜
• 粘着斑
• 黑色素体
• receptor complex
• 细胞膜
• integral component of plasma membrane
• ruffle membrane
• cell surface
• 细胞连接
• integrin complex
• platelet alpha granule membrane
• integrin alphav-beta3 complex
• 外排體
• lamellipodium membrane
• 细胞核
• microvillus membrane
• filopodium membrane
• alphav-beta3 integrin-IGF-1-IGF1R complex
• alphav-beta3 integrin-PKCalpha complex
• alphav-beta3 integrin-HMGB1 complex
• glutamatergic synapse
• 突触
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| 生物學過程 | • negative regulation of lipoprotein metabolic process
• apolipoprotein A-I-mediated signaling pathway
• positive regulation of vascular endothelial growth factor receptor signaling pathway
• positive regulation of protein phosphorylation
• regulation of cell migration
• negative chemotaxis
• positive regulation of endothelial cell proliferation
• tube development
• heterotypic cell-cell adhesion
• angiogenesis involved in wound healing
• 傷口癒合
• platelet degranulation
• 凝血
• extracellular matrix organization
• smooth muscle cell migration
• positive regulation of endothelial cell migration
• 增殖
• cell-substrate adhesion
• vascular endothelial growth factor receptor signaling pathway
• 細胞粘附
• positive regulation of peptidyl-tyrosine phosphorylation
• mesodermal cell differentiation
• cell-substrate junction assembly
• integrin-mediated signaling pathway
• negative regulation of lipid storage
• substrate adhesion-dependent cell spreading
• negative regulation of lipid transport
• cell-matrix adhesion
• viral process
• regulation of bone resorption
• platelet aggregation
• 细胞迁移
• negative regulation of macrophage derived foam cell differentiation
• activation of protein kinase activity
• leukocyte migration
• cell adhesion mediated by integrin
• platelet activation
• apoptotic cell clearance
• regulation of postsynaptic neurotransmitter receptor internalization
• regulation of protein localization
• regulation of serotonin uptake
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| Sources:Amigo / QuickGO |
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| 直系同源 |
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| 物種 | 人類 | 小鼠 |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| mRNA序列 | | |
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| 蛋白序列 | | |
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| 基因位置（UCSC） | Chr 17: 47.25 – 47.31 Mb | Chr 11: 104.5 – 104.56 Mb |
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| PubMed查找 | [5] | [6] |
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| 維基數據 |
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. PMID 2454952. doi:10.1172/JCI113548. 
