CVL-354
Chemical compound
| Clinical data | |
|---|---|
| Routes of administration | Oral administration |
| Drug class | Opioid antagonist; κ-Opioid receptor antagonist |
CVL-354 is an opioid antagonist which is under development for the treatment of major depressive disorder and substance-related disorders.[1][2]
It acts as a selective antagonist of the κ-opioid receptor.[1][2] The drug is also more weakly an antagonist of the μ-opioid receptor, with about 31-fold lower affinity and 27-fold lower inhibitory potency at the μ-opioid receptor relative to the κ-opioid receptor.[2] CVL-354 is taken by mouth.[1] It was originated by Pfizer and is under development by Cerevel Therapeutics.[1] As of September 2022, CVL-354 is in phase 1 clinical trials for major depressive disorder and is in the preclincal stage of development for substance-related disorders.[1]
See also
- κ-Opioid receptor § Antagonists
- List of investigational antidepressants § κ-Opioid receptor antagonists
References
- ^ a b c d e "CVL 354 – Cerevel therapeutics". Adis Insight. Springer Nature Switzerland AG.
- ^ a b c "ACNP 61st Annual Meeting: Poster Abstracts P271-P540". Neuropsychopharmacology. 47 (Suppl 1): 220–370. December 2022. doi:10.1038/s41386-022-01485-0. eISSN 1740-634X. PMC 9714399. PMID 36456694.
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Opioid receptor modulators
(MOR)
(DOR)
(KOR)
(NOP)
| Agonists |
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|---|---|
| Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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