Celiprolol

Pharmacokinetic dataBioavailability30-70%Elimination half-life5 hoursIdentifiersCAS NumberPubChem CIDDrugBankChemSpiderUNIIKEGGChEMBLCompTox Dashboard (EPA)ECHA InfoCard100.054.980 Chemical and physical dataFormulaC₂₀H₃₃N₃O₄Molar mass379.501 g·mol⁻¹3D model (JSmol)ChiralityRacemic mixture

Celiprolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.

It was patented in 1973 and approved for medical use in 1982.^[1]

Medical use

Celiprolol is believed to provide clinical benefit for people with vascular Ehlers–Danlos syndrome by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture.^[2] In 2019, a new drug application (NDA) for celiprolol was denied by the U.S. Food and Drug Administration (FDA), instead calling for an “adequate and well-controlled” trial to determine whether celiprolol reduced the risk of clinical events in patients with vEDS. ^[3]

Brand names

Brand names include Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm

References

External links

• Selectol Summary of Product Characteristics (from the IPHA Medicines Compendium)
• Celiprolol data sheet for New Zealand