HSPA4L

Protein-coding gene in the species Homo sapiens
HSPA4L
Identifiers
AliasesHSPA4L, APG-1, HSPH3, Osp94, heat shock protein family A (Hsp70) member 4 like, APG1
External IDsMGI: 107422; HomoloGene: 22610; GeneCards: HSPA4L; OMA:HSPA4L - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HSPA4L
Genomic location for HSPA4L
Band4q28.1Start127,781,821 bp[1]
End127,840,733 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HSPA4L
Genomic location for HSPA4L
Band3|3 BStart40,699,814 bp[2]
End40,750,538 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • Brodmann area 23

  • secondary oocyte

  • postcentral gyrus

  • pons

  • gonad

  • Pars compacta

  • bronchial epithelial cell
Top expressed in
  • spermatid

  • spermatocyte

  • neural layer of retina

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • zygote

  • ventricular zone

  • esophagus

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ATP binding
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
Biological process
  • response to unfolded protein
  • protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22824

18415

Ensembl

ENSG00000164070

ENSMUSG00000025757

UniProt

O95757

P48722

RefSeq (mRNA)

NM_014278
NM_001317381
NM_001317382
NM_001317383

NM_011020

RefSeq (protein)

NP_001304310
NP_001304311
NP_001304312
NP_055093

NP_035150

Location (UCSC)Chr 4: 127.78 – 127.84 MbChr 3: 40.7 – 40.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heat shock 70 kDa protein 4L is a protein that in humans is encoded by the HSPA4L gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164070 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nonoguchi K, Itoh K, Xue JH, Tokuchi H, Nishiyama H, Kaneko Y, Tatsumi K, Okuno H, Tomiwa K, Fujita J (Nov 1999). "Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes". Gene. 237 (1): 21–8. doi:10.1016/S0378-1119(99)00325-X. PMID 10524232.
  6. ^ "Entrez Gene: HSPA4L heat shock 70kDa protein 4-like".

Further reading

  • Nonoguchi K, Tokuchi H, Okuno H, Watanabe H, Egawa H, Saito K, Ogawa O, Fujita J (2001). "Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm". Int. J. Urol. 8 (6): 308–14. doi:10.1046/j.1442-2042.2001.00304.x. PMID 11389747. S2CID 27280317.
  • Matsumori M, Itoh H, Toyoshima I, Komatsuda A, Sawada K, Fukuda J, Tanaka T, Okubo A, Kinouchi H, Mizoi K, Hama T, Suzuki A, Hamada F, Otaka M, Shoji Y, Takada G (2003). "Characterization of the 105-kDa molecular chaperone. Identification, biochemical properties, and localization". Eur. J. Biochem. 269 (22): 5632–41. doi:10.1046/j.1432-1033.2002.03272.x. PMID 12423363.
  • Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS (2003). "Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells". J. Clin. Invest. 112 (5): 745–54. doi:10.1172/JCI17241. PMC 182184. PMID 12952923.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

  • v
  • t
  • e
Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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