UBE2C

Protein-coding gene in the species Homo sapiens
UBE2C
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1I7K, 4YII, 5A31

Identifiers
AliasesUBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDsOMIM: 605574; MGI: 1915862; HomoloGene: 5096; GeneCards: UBE2C; OMA:UBE2C - orthologs
EC number2.3.2.24
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for UBE2C
Genomic location for UBE2C
Band20q13.12Start45,812,576 bp[1]
End45,816,957 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for UBE2C
Genomic location for UBE2C
Band2 H3|2 85.27 cMStart164,611,818 bp[2]
End164,620,742 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • embryo

  • ganglionic eminence

  • oocyte

  • mucosa of transverse colon

  • gonad

  • bone marrow

  • secondary oocyte

  • thymus

  • trabecular bone
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • tail of embryo

  • zygote

  • genital tubercle

  • medial ganglionic eminence

  • ventricular zone

  • somite

  • otic placode

  • abdominal wall

  • morula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • protein binding
  • ATP binding
  • ubiquitin conjugating enzyme activity
  • ubiquitin protein ligase binding
  • ubiquitin-like protein ligase binding
Cellular component
  • cytoplasm
  • nucleoplasm
  • anaphase-promoting complex
  • cytosol
  • plasma membrane
  • ubiquitin ligase complex
  • nucleus
Biological process
  • free ubiquitin chain polymerization
  • ubiquitin-dependent protein catabolic process
  • exit from mitosis
  • positive regulation of exit from mitosis
  • protein K11-linked ubiquitination
  • cell division
  • protein K48-linked ubiquitination
  • regulation of mitotic metaphase/anaphase transition
  • cell cycle
  • anaphase-promoting complex-dependent catabolic process
  • positive regulation of ubiquitin protein ligase activity
  • protein ubiquitination
  • regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11065

68612

Ensembl

ENSG00000175063

ENSMUSG00000001403

UniProt

O00762
Q5TZN3

Q9D1C1

RefSeq (mRNA)
NM_001281741
NM_001281742
NM_007019
NM_181799
NM_181800

NM_181801
NM_181802
NM_181803

NM_026785

RefSeq (protein)
NP_001268670
NP_001268671
NP_008950
NP_861515
NP_861516

NP_861517
NP_008950.1

NP_081061

Location (UCSC)Chr 20: 45.81 – 45.82 MbChr 2: 164.61 – 164.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175063 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001403 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. Bibcode:1997PNAS...94.2362T. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
  6. ^ a b "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading

  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
  • Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10". J. Biol. Chem. 277 (24): 21913–21. doi:10.1074/jbc.M109398200. PMID 11927573.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme". Cancer Res. 63 (14): 4167–73. PMID 12874022.
  • Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
  • Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin". Oncogene. 23 (39): 6621–9. doi:10.1038/sj.onc.1207861. PMID 15208666.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
  • Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas". Br. J. Cancer. 93 (4): 464–71. doi:10.1038/sj.bjc.6602721. PMC 2361574. PMID 16106252.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH". Cancer Genet. Cytogenet. 168 (1): 30–5. doi:10.1016/j.cancergencyto.2005.12.011. PMID 16772118.
  • Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma". Neoplasia. 8 (12): 1062–71. doi:10.1593/neo.05832. PMC 1783715. PMID 17217624.
  • Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression". Int. J. Cancer. 121 (1): 33–8. doi:10.1002/ijc.22605. PMID 17354233. S2CID 12277353.
  • v
  • t
  • e
  • 1i7k: CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10
    1i7k: CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10
  • v
  • t
  • e
Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targeting
Ubiquitin
(ubiquitylation)
Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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