OR4E2

OR4E2
Identifiers
Aliases	OR4E2, OR14-42, olfactory receptor family 4 subfamily E member 2, olfactory receptor family 4 subfamily E member 2 (gene/pseudogene)
External IDs	MGI: 3031343; HomoloGene: 41378; GeneCards: OR4E2; OMA:OR4E2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,653,835 bp[1] End 21,667,642 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C2 Start 52,680,447 bp[2] End 52,690,031 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh renal cortex blood urinary bladder Top expressed in Jacobson's organ spermatid choroid plexus of fourth ventricle gastrula respiratory epithelium nasal epithelium olfactory epithelium spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity copper ion binding odorant binding Cellular component membrane plasma membrane integral component of membrane integral component of plasma membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26686 57271 Ensembl ENSG00000221977 ENSMUSG00000035626 UniProt Q8NGC2 Q7TQQ0 RefSeq (mRNA) NM_001001912 NM_020514 RefSeq (protein) NP_001001912 NP_001001912 NP_065260 Location (UCSC) Chr 14: 21.65 – 21.67 Mb Chr 14: 52.68 – 52.69 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 4E2 is a protein that in humans is encoded by the OR4E2 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

See also

• Olfactory receptor

References

Further reading

External links

• OR4E2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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