OR5F1

Protein-coding gene in the species Homo sapiens
OR5F1
Identifiers
AliasesOR5F1, OR11-10, olfactory receptor family 5 subfamily F member 1
External IDsOMIM: 608492; HomoloGene: 130524; GeneCards: OR5F1; OMA:OR5F1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5F1
Genomic location for OR5F1
Band11q12.1Start55,993,681 bp[1]
End55,994,625 bp[1]
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • membrane
  • plasma membrane
  • integral component of membrane
Biological process
  • signal transduction
  • response to stimulus
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

338674

n/a

Ensembl

ENSG00000149133

n/a

UniProt

O95221

n/a

RefSeq (mRNA)

NM_003697

n/a

RefSeq (protein)

NP_003688

n/a

Location (UCSC)Chr 11: 55.99 – 55.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 5F1 is a protein that in humans is encoded by the OR5F1 gene.[3][4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

See also

  • Olfactory receptor

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149133 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Buettner JA, Glusman G, Ben-Arie N, Ramos P, Lancet D, Evans GA (Dec 1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID 9787077.
  4. ^ a b "Entrez Gene: OR5F1 olfactory receptor, family 5, subfamily F, member 1".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
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Family 56
Class II
(tetrapod specific receptors)
Family 1
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Family 11
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