PNRC1

Protein-coding gene in the species Homo sapiens
PNRC1
Identifiers
AliasesPNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDsOMIM: 606714; MGI: 1917838; HomoloGene: 4960; GeneCards: PNRC1; OMA:PNRC1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PNRC1
Genomic location for PNRC1
Band6q15Start89,080,751 bp[1]
End89,085,160 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PNRC1
Genomic location for PNRC1
Band4|4 A5Start33,245,423 bp[2]
End33,290,163 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • gastric mucosa

  • left uterine tube

  • gastrocnemius muscle

  • left ovary

  • muscle of thigh

  • right ovary

  • tibial arteries

  • epithelium of colon

  • gallbladder
Top expressed in
  • left lung lobe

  • medial ganglionic eminence

  • granulocyte

  • lymph node

  • mesenteric lymph nodes

  • lacrimal gland

  • molar

  • thoracic diaphragm

  • submandibular gland

  • digastric muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • P-body
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • deadenylation-independent decapping of nuclear-transcribed mRNA
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10957

108767

Ensembl

ENSG00000146278

ENSMUSG00000040128

UniProt

Q12796
Q49A59

Q3TWH3

RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC)Chr 6: 89.08 – 89.09 MbChr 4: 33.25 – 33.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[5][6]

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146278 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040128 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
  6. ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
  7. ^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
  8. ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhou D, Chen B, Ye JJ, Chen S (2004). "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction". Oncogene. 23 (31): 5394–404. doi:10.1038/sj.onc.1207695. PMID 15122321.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. CiteSeerX 10.1.1.621.2877. doi:10.1074/jbc.274.32.22373. PMID 10428808. S2CID 15532327.

External links

  • v
  • t
  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF


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