Setastine
Chemical compound
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| Formula | C22H28ClNO |
| Molar mass | 357.92 g·mol−1 |
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Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]
Pharmacology
Pharmacodynamics
Setastine acts as a highly selective H1 receptor antagonist.[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.
Pharmacokinetics
Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.[3]
See also
- Clemastine
References
- ^ Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica. 39 (1): 22–24. PMID 1677500.
- ^ Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica. 37 (4): 202–204. PMID 2576575.
- ^ a b Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–1345. PMID 1982751.
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Decongestants and other nasal preparations (R01)
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| Antiallergic agents, excluding corticosteroids | |
| Corticosteroids | |
| Other nasal preparations | |
| Combination products |
Sympathomimetics
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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