GPR98

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G protein spregnuti receptor 98
Identifikatori
SimboliGPR98; FEB4; MASS1; USH2B; USH2C; VLGR1; VLGR1b
Vanjski IDOMIM: 602851 MGI: 1274784 HomoloGene: 19815 IUPHAR: GPR98 GeneCards: GPR98 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• vezivanje jona kalcijuma
• proteinsko vezivanje
• miozinsko vezivanje
Celularna komponenta • integralno sa ćelijskom membranom
• integralno sa membranom
Biološki proces • signalni put G protein spregnutog receptora
• neuropeptidni signalni put
• razvoj nervnog sistema
• senzorna percepcija zvuka
• međućelijska adhezija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez84059110789
EnsemblENSG00000164199ENSMUSG00000069170
UniProtQ8WXG9Q8VHN7
RefSeq (mRNA)NM_032119.3NM_054053.4
RefSeq (protein)NP_115495.3NP_473394.3
Lokacija (UCSC)Chr 5:
89.83 - 90.46 Mb		Chr 13:
81.23 - 81.77 Mb
PubMed pretraga[1][2]

G protein spregnuti receptor 98 je protein koji je kod ljudi kodiran GPR98 genom.[1]

Ovaj protein je član familije G protein spregnutih receptora. On vezuje kalcijum. Izražen je u centralnom nervnom sistemu. On je takođe poznat kao veoma veliki G-protein spregnuti receptor 1, jer je 6300 aminokiselina dug. On sadrži C-terminus 7-transmembranaskog domena uobičajene dužine, dok N-terminus ima 5900 ostataka uključujući 35 kalks-beta domena vezivanja kalcijuma, i 6 EAR domena. Mutacije ovog gena su asocirane sa Ušerovim sindromom 2. Nekoliko alternativno splajsovanih transkripta je opisano.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: GPR98 G protein-coupled receptor 98”. 

Literatura

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). „Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”. DNA Res. 9 (3): 99–106. DOI:10.1093/dnares/9.3.99. PMID 12168954. 
  • Staub E, Pérez-Tur J, Siebert R, et al. (2002). „The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.”. Trends Biochem. Sci. 27 (9): 441–4. DOI:10.1016/S0968-0004(02)02163-1. PMID 12217514. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). „Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”. DNA Res. 5 (3): 169–76. DOI:10.1093/dnares/5.3.169. PMID 9734811. 
  • Nakayama J, Hamano K, Iwasaki N, et al. (2000). „Significant evidence for linkage of febrile seizures to chromosome 5q14-q15.”. Hum. Mol. Genet. 9 (1): 87–91. DOI:10.1093/hmg/9.1.87. PMID 10587582. 
  • Pieke-Dahl S, Möller CG, Kelley PM, et al. (2000). „Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q.”. J. Med. Genet. 37 (4): 256–62. DOI:10.1136/jmg.37.4.256. PMC 1734554. PMID 10745043. 
  • Nikkila H, McMillan DR, Nunez BS, et al. (2001). „Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain.”. Mol. Endocrinol. 14 (9): 1351–64. DOI:10.1210/me.14.9.1351. PMID 10976914. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”. Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
  • Skradski SL, Clark AM, Jiang H, et al. (2001). „A novel gene causing a mendelian audiogenic mouse epilepsy.”. Neuron 31 (4): 537–44. DOI:10.1016/S0896-6273(01)00397-X. PMID 11545713. 
  • McMillan DR, Kayes-Wandover KM, Richardson JA, White PC (2002). „Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system.”. J. Biol. Chem. 277 (1): 785–92. DOI:10.1074/jbc.M108929200. PMID 11606593. 
  • Nagase T, Kikuno R, Ohara O (2002). „Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.”. DNA Res. 8 (6): 319–27. DOI:10.1093/dnares/8.6.319. PMID 11853319. 
  • Nakayama J, Fu YH, Clark AM, et al. (2002). „A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures.”. Ann. Neurol. 52 (5): 654–7. DOI:10.1002/ana.10347. PMID 12402266. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Weston MD, Luijendijk MW, Humphrey KD, et al. (2004). „Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II.”. Am. J. Hum. Genet. 74 (2): 357–66. DOI:10.1086/381685. PMC 1181933. PMID 14740321. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.”. Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201. 
  • Fu GK, Wang JT, Yang J, et al. (2005). „Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.”. Genomics 84 (1): 205–10. DOI:10.1016/j.ygeno.2004.01.011. PMID 15203218. 
  • Schwartz SB, Aleman TS, Cideciyan AV, et al. (2005). „Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.”. Invest. Ophthalmol. Vis. Sci. 46 (2): 734–43. DOI:10.1167/iovs.04-1136. PMID 15671307. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 

Spoljašnje veze

  • GeneReviews/NCBI/NIH/UW entry on Usher Syndrome Type II
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)