Receptor slobodnih masnih kiselina 1

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Receptor slobodnih masnih kiselina 1
Identifikatori
SimboliFFAR1; FFA1R; GPCR40; GPR40
Vanjski IDOMIM: 603820 MGI: 2684079 HomoloGene: 3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Ontologija gena
Molekularna funkcija • aktivnost G-protein spregnutog receptora
• aktivnost faktora guanil-nukleotidne razmene
• vezivanje masne kiseline
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • metabolički proces energetske rezerve
• signalni put G-protein spregnutog receptora
• pozitivna regulacija kalcijumskog jonskog transporta u citozol
Ortolozi
VrstaČovekMiš
Entrez2864233081
EnsemblENSG00000126266ENSMUSG00000044453
UniProtO14842Q76JU9
RefSeq (mRNA)NM_005303.2NM_194057.2
RefSeq (protein)NP_005294.1NP_918946.2
Lokacija (UCSC)Chr 19:
35.84 - 35.84 Mb		Chr 7:
31.65 - 31.65 Mb
PubMed pretraga[1][2]

Receptor slobodnih masnih kiselina 1 (FFA1) je G protein spregnuti receptor kodiran ljudskim genom FFAR1.[1] On je u znatnoj meri izražen u ćelijama pankreasa, a u manjoj meri u materici i mozgu.[2]

Reference

  1. ↑ „Entrez Gene: FFAR1 free fatty acid receptor 1”. 
  2. ↑ „UniGene: EST profile FFAR1 free fatty acid receptor 1”. 

Literatura

  • Brown AJ, Jupe S, Briscoe CP (2005). „A family of fatty acid binding receptors.”. DNA Cell Biol. 24 (1): 54–61. DOI:10.1089/dna.2005.24.54. PMID 15684720. 
  • Sawzdargo M, George SR, Nguyen T, et al. (1997). „A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.”. Biochem. Biophys. Res. Commun. 239 (2): 543–7. DOI:10.1006/bbrc.1997.7513. PMID 9344866. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Briscoe CP, Tadayyon M, Andrews JL, et al. (2003). „The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.”. J. Biol. Chem. 278 (13): 11303–11. DOI:10.1074/jbc.M211495200. PMID 12496284. 
  • Kotarsky K, Nilsson NE, Flodgren E, et al. (2003). „A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.”. Biochem. Biophys. Res. Commun. 301 (2): 406–10. DOI:10.1016/S0006-291X(02)03064-4. PMID 12565875. 
  • Itoh Y, Kawamata Y, Harada M, et al. (2003). „Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.”. Nature 422 (6928): 173–6. DOI:10.1038/nature01478. PMID 12629551. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Hardy S, St-Onge GG, Joly E, et al. (2005). „Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.”. J. Biol. Chem. 280 (14): 13285–91. DOI:10.1074/jbc.M410922200. PMID 15695516. 
  • Ogawa T, Hirose H, Miyashita K, et al. (2005). „GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.”. Metab. Clin. Exp. 54 (3): 296–9. DOI:10.1016/j.metabol.2004.09.008. PMID 15736105. 
  • Tomita T, Masuzaki H, Noguchi M, et al. (2006). „GPR40 gene expression in human pancreas and insulinoma.”. Biochem. Biophys. Res. Commun. 338 (4): 1788–90. DOI:10.1016/j.bbrc.2005.10.161. PMID 16289108. 
  • Tomita T, Masuzaki H, Iwakura H, et al. (2006). „Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.”. Diabetologia 49 (5): 962–8. DOI:10.1007/s00125-006-0193-8. PMID 16525841. 
  • Stoddart LA, Brown AJ, Milligan G (2007). „Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.”. Mol. Pharmacol. 71 (4): 994–1005. DOI:10.1124/mol.106.031534. PMID 17200419. 
  • Bartoov-Shifman R, Ridner G, Bahar K, et al. (2007). „Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.”. J. Biol. Chem. 282 (32): 23561–71. DOI:10.1074/jbc.M702115200. PMID 17525159. 
  • Sum CS, Tikhonova IG, Neumann S, et al. (2007). „Identification of residues important for agonist recognition and activation in GPR40.”. J. Biol. Chem. 282 (40): 29248–55. DOI:10.1074/jbc.M705077200. PMID 17699519. 

Vidi još

Spoljašnje veze

  • „Free Fatty Acid Receptors: FFA1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)