EEF1E1

Protein-coding gene in the species Homo sapiens
EEF1E1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2UZ8, 4BL7, 4BVX, 4BVY, 5BMU

Identifiers
AliasesEEF1E1, AIMP3, P18, eukaryotic translation elongation factor 1 epsilon 1
External IDsOMIM: 609206; MGI: 1913393; HomoloGene: 3161; GeneCards: EEF1E1; OMA:EEF1E1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for EEF1E1
Genomic location for EEF1E1
Band6p24.3Start8,073,360 bp[1]
End8,102,559 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for EEF1E1
Genomic location for EEF1E1
Band13|13 A3.3Start38,828,183 bp[2]
End38,843,034 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • oocyte

  • right testis

  • left testis

  • islet of Langerhans

  • gonad

  • testicle

  • C1 segment

  • embryo

  • right adrenal gland
Top expressed in
  • medial ganglionic eminence

  • endocardial cushion

  • superior cervical ganglion

  • migratory enteric neural crest cell

  • morula

  • barrel cortex

  • atrioventricular valve

  • yolk sac

  • neural layer of retina

  • interventricular septum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • glutathione transferase activity
Cellular component
  • nucleoplasm
  • nucleolus
  • nucleus
  • cytoplasm
  • aminoacyl-tRNA synthetase multienzyme complex
  • cytosol
Biological process
  • positive regulation of apoptotic process
  • positive regulation of DNA damage response, signal transduction by p53 class mediator
  • tRNA aminoacylation for protein translation
  • protein biosynthesis
  • positive regulation of cellular senescence
  • negative regulation of cell population proliferation
  • glutathione metabolic process
  • cellular response to leukemia inhibitory factor
  • positive regulation of apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9521

66143

Ensembl

ENSG00000124802

ENSMUSG00000001707

UniProt

O43324

Q9D1M4

RefSeq (mRNA)

NM_004280
NM_001135650

NM_025380

RefSeq (protein)

NP_001129122
NP_004271

NP_079656

Location (UCSC)Chr 6: 8.07 – 8.1 MbChr 13: 38.83 – 38.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124802 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  6. ^ "Entrez Gene: EEF1E1 eukaryotic translation elongation factor 1 epsilon 1".

Further reading

  • Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol. Chem. 266 (23): 15398–405. doi:10.1016/S0021-9258(18)98629-1. PMID 1651330.
  • Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. doi:10.1016/S0014-5793(03)00362-4. PMID 12729910. S2CID 39222196.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Park BJ, Kang JW, Lee SW, et al. (2005). "The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR". Cell. 120 (2): 209–21. doi:10.1016/j.cell.2004.11.054. PMID 15680327. S2CID 12989946.

External links

  • Overview of all the structural information available in the PDB for UniProt: O43324 (Human Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts


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